Anti-neutrophil cytoplasmic autoantibody (ANCA) profiles in propylthiouracil-induced lupus-like manifestations in monozygotic triplets with hyperthyroidism

被引：18
作者：
Herlin, T [1 ]
Birkebæk, NH
Wolthers, OD
Heegaard, NHH
Wiik, A
机构：
[1] Aarhus Univ Hosp, Pediat Rheumatol Clin, Dept Pediat, Skejby Sygehus, DK-8200 Aarhus N, Denmark
[2] Statens Serum Inst, Dept Autoimmunol, DK-2300 Copenhagen, Denmark
来源：
SCANDINAVIAN JOURNAL OF RHEUMATOLOGY | 2002年 / 31卷 / 01期
关键词：
drug-induced lupus erythematosus; propylthiouracil; ANCA;
D O I：
10.1080/030097402317255381
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
We describe the ANCA profile of two monozygotic triplets (A and B) treated with propylthiouracil (PTU) for hyperthyroidism who developed LE-like manifestations. Triplet C also developed hyperthyroidism but was not treated with PTU and never experienced LE-like symptoms. Triplet A and B showed a marked rise in P-ANCA titer to 1:1290 after PTU was introduced whereas triplet C never had a titer higher than 1:80. Consecutive sera were investigated for ANCA to six different neutrophil granule proteins. Triplet A and B, but not C. both developed a strongly positive elastase-ANCA. Our results confirm the importance of a genetic factor influencing the susceptibility to drug-induced LE.
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收藏
页码：46 / 49
页数：4
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