Distinct Characteristics of Inferonasal Fundus Autofluorescence Patterns in Stargardt Disease and Retinitis Pigmentosa

被引：28

作者：

Duncker, Tobias ^{[1
]}

Lee, Winston ^{[1
]}

Tsang, Stephen H. ^{[1
,2
]}

Greenberg, Jonathan P. ^{[1
]}

Zernant, Jana ^{[1
]}

Allikmets, Rando ^{[1
,2
]}

Sparrow, Janet R. ^{[1
,2
]}

机构：

[1] Columbia Univ, Dept Ophthalmol, New York, NY 10032 USA

[2] Columbia Univ, Dept Pathol & Cell Biol, New York, NY 10032 USA

来源：

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE | 2013年 / 54卷 / 10期

基金：

美国国家卫生研究院;

关键词：

ABCA4; fundus autofluorescence; lipofuscin; melanin; optic fissure; retinal pigment epithelium; retinitis pigmentosa; scanning laser ophthalmoscope; recessive Stargardt disease; SHORT-WAVELENGTH AUTOFLUORESCENCE; MACULAR DYSTROPHY; LIPOFUSCIN; GENE; ABCR; FLAVIMACULATUS; ABNORMALITIES; VISUALIZATION; FLUORESCENCE; MUTATIONS;

D O I：

10.1167/iovs.13-12895

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

PURPOSE. To report distinct characteristics of fundus autofluorescence (AF) patterns inferior to the optic disc in recessive Stargardt disease (STGD1) and retinitis pigmentosa (RP). METHODS. Short-wavelength (SW) and near-infrared (NIR) AF images were acquired from patients with STGD1 and RP. In SW-and NIR-AF images of STGD1 patients, gray levels (GL) on both sides of the demarcation line were measured. RESULTS. In STGD1, a demarcation line, which has been assigned to the closed optic fissure, was visible on SW-AF and NIR-AF inferior to the optic disc. In healthy subjects, this demarcation line is only visible by SW-AF. At 208 inferior to the disc center, AF levels on the nasal side were 25% (+/-11%) lower than on the temporal side in SW-AF images and 18% (+/-11%) lower in NIR-AF images. For both STGD1 and RP, the inferonasal quadrant exhibited distinct SW-and NIR-AF patterns compared with other fundus areas. Disease-related AF changes, such as flecks, appeared to respect the demarcation line as a boundary. CONCLUSIONS. Disease-related AF patterns originating in RPE in STGD1 and RP appear to respect the demarcation line in the inferonasal quadrant of the fundus as a border. The visibility of the inferonasal demarcation line by NIR-AF in STGD1 but not in healthy eyes may indicate that increased levels of RPE lipofuscin modulate the melanin-related NIR-AF signal. This feature of NIR-AF images may aid in the diagnosis of STGD1 patients.

引用

页码：6820 / 6826

页数：7

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