A (15;17) translocation not associated with acute promyelocytic leukaemia

被引：13

作者：

DiBona, E

Montaldi, A

Guercini, N

Rossi, V

Luciano, A

Biondi, A

Rodeghiero, F

机构：

[1] SAN BORTOLO HOSP,DEPT HAEMATOL,I-36100 VICENZA,ITALY

[2] SAN BORTOLO HOSP,CTR HUMAN GENET,I-36100 VICENZA,ITALY

[3] UNIV MILAN,DEPT PAEDIAT,MONZA,ITALY

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 1996年 / 95卷 / 04期

关键词：

t(15; 17) translocation; chromosomal abnormality; acute myeloid leukaemia; acute promyelocytic leukaemia; fluorescence in situ hybridization;

D O I：

10.1046/j.1365-2141.1996.d01-1949.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We report a woman with acute myeloid leukaemia (AML) type M2 according to FAB classification, showing a t(15;17) apparently identical to that of acute promyelocytic leukaemia (APL) on conventional cytogenetic analysis. Fluorescence in situ hybridization (FISH) using cosmidic probes specific for RAR alpha and PML regions did not show a fusion signal as in APL. The breakpoints were assigned to 15q24.3 and 17q21.1. Detailed molecular analyses did not reveal any involvement of RAR alpha and PML genes. The patient was resistant to several front-line AML treatments and to all-trans retinoic acid (ATRA). These findings reinforce FISH and RT-PCR as useful tools for the characterization of a t(15;17) as the translocation specifically associated with APL.

引用

页码：706 / 709

页数：4

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