Evolution of Resistance in Cancer: A Cell Cycle Perspective

被引：17
作者：
Dokumcu, Kagan [1 ]
Farahani, Ramin M. [1 ,2 ]
机构：
[1] Univ Sydney, Fac Med & Hlth, Dept Life Sci, Sydney, NSW, Australia
[2] IDR Westmead Inst Med Res, Westmead, NSW, Australia
来源：
FRONTIERS IN ONCOLOGY | 2019年 / 9卷
关键词：
mutagenesis; cell cycle; quiescence; tolerance; resistance; DEPENDENT PROTEIN-KINASE; STRAND BREAK REPAIR; HOMOLOGOUS RECOMBINATION; TUMOR DORMANCY; DNA-REPAIR; AUTOPHAGY; MTOR; PHOSPHORYLATION; CONSEQUENCES; SUPPRESSION;
D O I：
10.3389/fonc.2019.00376
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Resistance of neoplastic cells to therapy is considered a key challenge in the treatment of cancer. Emergence of resistance is commonly attributed to the gradual mutational evolution of neoplastic cells. However, accumulating evidence suggests that exogenous stressors could significantly accelerate the emergence of resistant clones during the course of treatment. Herein, we review molecular mechanisms that regulate the evolution of resistance in a tumor with particular emphasis on the role of cell cycle.
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页数：5
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