The measurement ex vivo of the resistance of low density lipoprotein (LDL) to oxidation promoted by copper is now being used in surveys of human populations at risk of developing atherosclerosis. However, it is not known whether a relationship between LDL oxidisability measured in this way and the development of atherosclerotic lesions exists. Using Watanabe rabbits as a model of the disease, we have found that dietary supplementation with the antioxidants, probucol and a-tocopherol, increased the resistance of LDL isolated from small volumes of plasma to oxidation. The antioxidant effects of probucol incorporated into LDL through dietary supplementation were greater than when incorporated ex vivo. When dietary supplementation was extended to a period of three months; the well established anti-atherosclerotic effects of probucol were confirmed and a highly significant relationship between the probucol content of the LDL particle and the extent of the atherosclerotic lesion in the aorta emerged. These results suggest that the assessment of the resistance of LDL isolated from plasma to oxidation promoted by copper may reflect the response of the arterial atherosclerotic process to antioxidant therapy.
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Univ Fed Santa Maria, Dept Quim, CCNE, BR-97105900 Santa Maria, RS, BrazilUniv Fed Santa Maria, Dept Quim, CCNE, BR-97105900 Santa Maria, RS, Brazil
Portella, Rafael de Lima
Barcelos, Romulo Pillon
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Univ Fed Santa Maria, Dept Quim, CCNE, BR-97105900 Santa Maria, RS, BrazilUniv Fed Santa Maria, Dept Quim, CCNE, BR-97105900 Santa Maria, RS, Brazil
Barcelos, Romulo Pillon
de Bem, Andreza Fabro
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Univ Fed Santa Maria, Ctr Ciencias Biol, Dept Bioquim, Florianopolis, SC, BrazilUniv Fed Santa Maria, Dept Quim, CCNE, BR-97105900 Santa Maria, RS, Brazil
de Bem, Andreza Fabro
Carratu, Vanessa Santana
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Fundacdo Univ Rio Grande, Dept Quim, Rio Grande, RS, BrazilUniv Fed Santa Maria, Dept Quim, CCNE, BR-97105900 Santa Maria, RS, Brazil
Carratu, Vanessa Santana
Bresolin, Leandro
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Univ Fed Acre, Cruzeiro Do Sul, AC, BrazilUniv Fed Santa Maria, Dept Quim, CCNE, BR-97105900 Santa Maria, RS, Brazil
Bresolin, Leandro
Teixeira da Rocha, Joao Batista
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Univ Fed Santa Maria, Dept Quim, CCNE, BR-97105900 Santa Maria, RS, BrazilUniv Fed Santa Maria, Dept Quim, CCNE, BR-97105900 Santa Maria, RS, Brazil
Teixeira da Rocha, Joao Batista
Antunes Soares, Felix Alexandre
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Univ Fed Santa Maria, Dept Quim, CCNE, BR-97105900 Santa Maria, RS, BrazilUniv Fed Santa Maria, Dept Quim, CCNE, BR-97105900 Santa Maria, RS, Brazil
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Univ Fed Santa Maria, Dept Quim, CCNE, BR-97105900 Santa Maria, RS, BrazilUniv Fed Santa Maria, Dept Quim, CCNE, BR-97105900 Santa Maria, RS, Brazil
Portella, Rafael de Lima
Barcelos, Romulo Pillon
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Univ Fed Santa Maria, Dept Quim, CCNE, BR-97105900 Santa Maria, RS, BrazilUniv Fed Santa Maria, Dept Quim, CCNE, BR-97105900 Santa Maria, RS, Brazil
Barcelos, Romulo Pillon
de Bem, Andreza Fabro
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h-index: 0
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Univ Fed Santa Maria, Ctr Ciencias Biol, Dept Bioquim, Florianopolis, SC, BrazilUniv Fed Santa Maria, Dept Quim, CCNE, BR-97105900 Santa Maria, RS, Brazil
de Bem, Andreza Fabro
Carratu, Vanessa Santana
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Fundacdo Univ Rio Grande, Dept Quim, Rio Grande, RS, BrazilUniv Fed Santa Maria, Dept Quim, CCNE, BR-97105900 Santa Maria, RS, Brazil
Carratu, Vanessa Santana
Bresolin, Leandro
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h-index: 0
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Univ Fed Acre, Cruzeiro Do Sul, AC, BrazilUniv Fed Santa Maria, Dept Quim, CCNE, BR-97105900 Santa Maria, RS, Brazil
Bresolin, Leandro
Teixeira da Rocha, Joao Batista
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h-index: 0
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Univ Fed Santa Maria, Dept Quim, CCNE, BR-97105900 Santa Maria, RS, BrazilUniv Fed Santa Maria, Dept Quim, CCNE, BR-97105900 Santa Maria, RS, Brazil
Teixeira da Rocha, Joao Batista
Antunes Soares, Felix Alexandre
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h-index: 0
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Univ Fed Santa Maria, Dept Quim, CCNE, BR-97105900 Santa Maria, RS, BrazilUniv Fed Santa Maria, Dept Quim, CCNE, BR-97105900 Santa Maria, RS, Brazil