Treatment outcomes of oxaliplatin, 5-FU, and leucovorin as salvage therapy for patients with advanced or metastatic gastric cancer: a retrospective analysis

被引：16

作者：

Seo, Hee Yeon ^{[1
]}

Kim, Dae Sik ^{[1
]}

Choi, Yoon Seok ^{[1
]}

Sung, Hwa Jung ^{[1
]}

Park, Kyong Hwa ^{[1
]}

Choi, In Keun ^{[1
]}

Kim, Seok Jin ^{[1
]}

Oh, Sang Cheul ^{[1
]}

Seo, Jae Hong ^{[1
]}

Choi, Chul Won ^{[1
]}

Kim, Byung Soo ^{[1
]}

Shin, Sang Won ^{[1
]}

Kim, Yeul Hong ^{[1
]}

Kim, Jun Suk ^{[1
]}

机构：

[1] Korea Univ, Coll Med, Anam Hosp, Div Oncol Hematol,Dept Internal Med,Med Ctr, Seoul 136705, South Korea

来源：

CANCER CHEMOTHERAPY AND PHARMACOLOGY | 2009年 / 63卷 / 03期

关键词：

Oxaliplatin; 5-Fluorouracil; Salvage therapy; Gastric cancer; MULTICENTER PHASE-II; LOW-DOSE LEUCOVORIN; FOLINIC ACID; INFUSIONAL FLUOROURACIL; 1ST-LINE TREATMENT; COLORECTAL-CANCER; 5-FLUOROURACIL; CHEMOTHERAPY; CISPLATIN; COMBINATION;

D O I：

10.1007/s00280-008-0753-3

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We performed a single-institution retrospective study to evaluate the efficacy and toxicities of oxaliplatin, 5-fluorouracil (5-FU), leucovorin (LV) combination chemotherapy as salvage treatment in patients with metastatic or advanced gastric cancer. Sixty-two patients with advanced gastric cancer previously treated were eligible for the study. Patients received oxaliplatin 100 mg/m(2) and LV 100 mg/m(2) (2-h intravenous infusion) followed by 5-FU 2,400 mg/m(2) (46-h continuous infusion) every 2 weeks, and responses were assessed after every three cycles. Fifty-nine out of 62 patients were assessable for response. Among them, 46 patients had previously been treated with cisplatin based chemotherapy. Patients had a median age of 57 years (range 32-76 years), 72.6% had an Eastern Cooperative Oncology Group performance status of 0 or 1. Total 296 courses of chemotherapy were administered as second-line (67.7%) or third-line (27.4%), and the median courses per patient was three cycles. Out of 59 evaluable patients, 14 partial responses were observed (overall response rate, 22.6%). Stable disease was observed in 22 patients (35.5%), and progressive disease in 23 patients (37.1%). The median response duration, time to progression, and overall survival were 2.3, 3.0, and 8.0 months, respectively. The major toxicities were neutropenia, mucositis, and peripheral neuropathy. Grade 3 or 4 hematologic toxicities included neutropenia in nine patients (14.5%) and thrombocytopenia in one patient (1.6%). Other grade 3 or 4 toxicities included mucositis in one patient (1.6%) and vomiting in two patients (3.2%). Grade 1 or 2 peripheral neuropathy were observed in 18 patients (29.0%), however there were no cases of grade 3 or 4 peripheral neuropathy and no treatment-related deaths. The combination of oxaliplatin, 5-FU and LV was effective and safe salvage chemotherapy in advanced gastric cancer patients.

引用

页码：433 / 439

页数：7