Pd(II)-Catalyzed Ph2(O)P-Directed C-H Olefination toward Phosphine-Alkene Ligands

被引：88
|
作者：
Wang, Hong-Li [1 ]
Hu, Rong-Bin [1 ]
Zhang, Heng [1 ]
Zhou, An-Xi [1 ]
Yang, Shang-Dong [1 ,2 ]
机构：
[1] Lanzhou Univ, State Key Lab Appl Organ Chem, Lanzhou 730000, Peoples R China
[2] Chinese Acad Sci, Lanzhou Inst Chem Phys, State Key Lab Oxo Synth & Select Oxidat, Lanzhou 730000, Peoples R China
来源：
ORGANIC LETTERS | 2013年 / 15卷 / 20期
关键词：
CATALYZED ASYMMETRIC 1,4-ADDITION; ARYL HYDROGEN PHOSPHATES; DIRECTING GROUP; BOND FORMATION; ACTIVATION; ALKENYLATION; RHODIUM(III); C(SP(2))-H; ARYLATION; VERSATILE;
D O I：
10.1021/ol402577p
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The Pd(II)-catalyzed Ph-2(O)P-directed C-H olefination to synthesize alkene-phosphine compounds is reported. In contrast to previous examples of various directing groups that guide selective C-H activation, the Ph-2(O)P group not only acts as the directing group but also serves to construct the alkene-phosphine ligands. The monoprotected amino acid (MPAA) ligand Ac-Leu-OH is found to promote this reaction in a significant manner.
引用
收藏
页码：5302 / 5305
页数：4
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