A novel circular RNA hsa_circ_0008035 contributes to gastric cancer tumorigenesis through targeting the miR-375/YBX1 axis

被引：5
|
作者：
Huang, Shifang [1 ]
Zhang, Xiaolin [4 ]
Guan, Bingsheng [2 ]
Sun, Peng [2 ]
Hong, Chong Tsz [2 ]
Peng, Juzheng [2 ]
Tang, Shaohui [3 ]
Yang, Jingge [2 ]
机构：
[1] Jinan Univ, Affiliated Hosp 1, Intens Care Unit, Guangzhou 510630, Guangdong, Peoples R China
[2] Jinan Univ, Dept Gastrointestinal Surg, Guangzhou 510630, Guangdong, Peoples R China
[3] Jinan Univ, Dept Gastroenterol, Guangzhou 510630, Guangdong, Peoples R China
[4] Heze Municipal Hosp, Dept Gastrointestinal Surg, Heze 274031, Peoples R China
来源：
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH | 2019年 / 11卷 / 04期
关键词：
Gastric cancer; hsa_circ_0008035; miR-375; YBX1; EXPRESSION; PROGRESSION; BINDING; CERNA;
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Circular RNAs (circRNAs) play an important regulatory role in a variety of human cancers, including gastric cancer. The mechanisms for the circRNAs in gastric cancers are not fully understood. This study aims to uncover the mechanism by which circRNAs regulate gastric cancer tumorigenesis. Among the microarray data, we screened dysregulated circRNAs and identified an up-regulated circRNA, hsa_circ_0008035. Functionally, the hsa_ circ_0008035 silencing by the siRNA transfection inhibited the proliferation and invasion of gastric cancer cells. Mechanically, hsa_circ_0008035 acted as a sponge for the miR-375 and absorbed its expression, and miR-375 was found to target YBX1 3'-UTR, constructing a hsa_circ_0008035/miR-375/YBX1 axis. Taken together, these findings are evidence that circRNA hsa_circ 0008035 promotes gastric cancer cell proliferation and invasion by regulating miR-375/YBX1.
引用
收藏
页码：2455 / 2462
页数：8
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