IL-18 receptor expression on epithelial cells is upregulated by TNF alpha

被引：13

作者：

Krásná, E ^{[1
]}

Kolesár, L ^{[1
]}

Slavcev, A ^{[1
]}

Valhová, S ^{[1
]}

Kronosová, B ^{[1
]}

Jaresová, M ^{[1
]}

Stríz, I ^{[1
]}

机构：

[1] Inst Clin & Expt Med IKEM, Dept Immunol, Prague 14021 4, Czech Republic

来源：

INFLAMMATION | 2005年 / 29卷 / 01期

关键词：

IL-18; IL-18R; epithelial cells; cytokines;

D O I：

10.1007/s10753-006-8967-1

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

IL-18 is a multifunctional cytokine that augments both innate and acquired immunity and potentiates Th1 and Th2 reactions. We studied the expression of IL-18 receptor (IL-18R) on renal and respiratory epithelial cell lines. Both cell lines upregulated IL-18R mRNA and IL-18R membrane expression in response to TNF alpha and other proinflammatory cytokines. The function of IL-18R was confirmed by induction of IL-8 release from epithelial cells in response to recombinant IL-18. Epithelial cells may represent an important target for IL-18, mainly under inflammatory conditions associated with TNF alpha release.

引用

页码：33 / 37

页数：5

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