Microencapsulation of Chemotherapeutics into Monodisperse and Tunable Biodegradable Polymers via Electrified Liquid Jets: Control of Size, Shape, and Drug Release

被引：48
作者：
Fattahi, Pouria [4 ,5 ]
Borhan, Ali [5 ]
Abidian, Mohammad Reza [1 ,2 ,3 ]
机构：
[1] Penn State Univ, Mat Res Inst, Dept Bioengn, University Pk, PA 16802 USA
[2] Penn State Univ, Mat Res Inst, Dept Mat Sci & Engn, University Pk, PA 16802 USA
[3] Penn State Univ, Mat Res Inst, Dept Chem Engn, University Pk, PA 16802 USA
[4] Penn State Univ, Dept Bioengn, University Pk, PA 16802 USA
[5] Penn State Univ, Dept Chem Engn, University Pk, PA 16802 USA
来源：
ADVANCED MATERIALS | 2013年 / 25卷 / 33期
关键词：
electrojetting; microcapsules; drug delivery; biomaterials; mathematical modeling; brain tumor; ANTITUMOR-ACTIVITY; IN-VITRO; DELIVERY; MICROSPHERES; NANOFIBERS; MEMBRANE; GLIOMA; BCNU; GLIADEL(R); EFFICIENCY;
D O I：
10.1002/adma.201301033
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
This paper describes microencapsulation of antitumor agent 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU, Carmustine) into biodegradable polymer poly(lactic-co-glycolic) acid (PLGA) using an electrojetting technique. The resulting BCNU-loaded PLGA microcapsules have significantly higher drug encapsulation efficiency, more tunable drug loading capacity, and (3) narrower size distribution than those generated using other encapsulation methods. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
引用
收藏
页码：4555 / 4560
页数：6
相关论文
共 42 条
[31]   Biodegradable nanoparticles for drug and gene delivery to cells and tissue [J].
Panyam, Jayanth ;
Labhasetwar, Vinod .
ADVANCED DRUG DELIVERY REVIEWS, 2012, 64 :61-71
[32]   A phase I trial of continuously infused intratumoral bleomycin for the treatment of recurrent glioblastoma multiforme [J].
Patchell, RA ;
Regine, WF ;
Ashton, P ;
Tibbs, PA ;
Wilson, D ;
Shappley, D ;
Young, B .
JOURNAL OF NEURO-ONCOLOGY, 2002, 60 (01) :37-42
[33]   Nanometre diameter fibres of polymer, produced by electrospinning [J].
Reneker, DH ;
Chun, I .
NANOTECHNOLOGY, 1996, 7 (03) :216-223
[34]   BCNU-loadedpoly(D, L-lactide-co-glycolide) wafer and antitumor activity against XF-498 human CNS tumor cells in vitro [J].
Seong, H ;
An, TK ;
Khang, G ;
Choi, SU ;
Lee, CO ;
Lee, HB .
INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2003, 251 (1-2) :1-12
[35]   An axisymmetric flow-focusing microfluidic device [J].
Takeuchi, S ;
Garstecki, P ;
Weibel, DB ;
Whitesides, GM .
ADVANCED MATERIALS, 2005, 17 (08) :1067-+
[36]   Release characteristics of four model drugs from drug-loaded electrospun cellulose acetate fiber mats [J].
Tungprapa, Santi ;
Jangchud, Ittipol ;
Supaphol, Pitt .
POLYMER, 2007, 48 (17) :5030-5041
[37]   Intratumoral doxorubicin in patients with malignant brain gliomas [J].
Voulgaris, S ;
Partheni, M ;
Karamouzis, M ;
Dimopoulos, P ;
Papadakis, N ;
Kalofonos, HP .
AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS, 2002, 25 (01) :60-64
[38]   Enzyme immobilization on electrospun polymer nanofibers: An overview [J].
Wang, Zhen-Gang ;
Wan, Ling-Shu ;
Liu, Zhen-Mei ;
Huang, Xiao-Jun ;
Xu, Zhi-Kang .
JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC, 2009, 56 (04) :189-195
[39]   Preparation of uniform-sized PELA microspheres with high encapsulation efficiency of antigen by premix membrane emulsification [J].
Wei, Qiang ;
Wei, Wei ;
Tian, Rui ;
Wang, Lian-yan ;
Su, Zhi-Guo ;
Ma, Guang-Hui .
JOURNAL OF COLLOID AND INTERFACE SCIENCE, 2008, 323 (02) :267-273
[40]   Gliadel® wafer in initial surgery for malignant glioma:: long-term follow-up of a multicenter controlled trial [J].
Westphal, M ;
Ram, Z ;
Riddle, V ;
Hilt, D ;
Bortey, E .
ACTA NEUROCHIRURGICA, 2006, 148 (03) :269-275
12345