Microencapsulation of Chemotherapeutics into Monodisperse and Tunable Biodegradable Polymers via Electrified Liquid Jets: Control of Size, Shape, and Drug Release

被引：48

作者：

Fattahi, Pouria ^{[4
,5
]}

Borhan, Ali ^{[5
]}

Abidian, Mohammad Reza ^{[1
,2
,3
]}

机构：

[1] Penn State Univ, Mat Res Inst, Dept Bioengn, University Pk, PA 16802 USA

[2] Penn State Univ, Mat Res Inst, Dept Mat Sci & Engn, University Pk, PA 16802 USA

[3] Penn State Univ, Mat Res Inst, Dept Chem Engn, University Pk, PA 16802 USA

[4] Penn State Univ, Dept Bioengn, University Pk, PA 16802 USA

[5] Penn State Univ, Dept Chem Engn, University Pk, PA 16802 USA

来源：

ADVANCED MATERIALS | 2013年 / 25卷 / 33期

关键词：

electrojetting; microcapsules; drug delivery; biomaterials; mathematical modeling; brain tumor; ANTITUMOR-ACTIVITY; IN-VITRO; DELIVERY; MICROSPHERES; NANOFIBERS; MEMBRANE; GLIOMA; BCNU; GLIADEL(R); EFFICIENCY;

D O I：

10.1002/adma.201301033

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

This paper describes microencapsulation of antitumor agent 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU, Carmustine) into biodegradable polymer poly(lactic-co-glycolic) acid (PLGA) using an electrojetting technique. The resulting BCNU-loaded PLGA microcapsules have significantly higher drug encapsulation efficiency, more tunable drug loading capacity, and (3) narrower size distribution than those generated using other encapsulation methods. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：4555 / 4560

页数：6

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