The effect of 6% Hydroxyethyl starch vs. Ringer's lactate on acute kidney injury after renal ischemia in rats

被引：7

作者：

Fernandes de Azevedo, Vera Lucia ^{[1
]}

Santana Santos, Paulo Sergio ^{[1
]}

de Oliveira, Gildasio Silveira, Jr. ^{[2
]}

Modolo, Gabriel Pinheiro ^{[3
]}

Custodio Domingues, Maria Aparecida ^{[4
]}

Machado Castiglia, Yara Marcondes ^{[5
]}

Galvao Vianna, Pedro Thadeu ^{[5
]}

Vane, Luiz Antonio ^{[5
]}

Pinheiro Modolo, Norma Sueli ^{[5
]}

机构：

[1] Univ Estadual Paulista, Botucatu Med Sch, Postgrad Program Anesthesiol, Sao Paulo, Brazil

[2] Northwestern Univ, Feinberg Sch Med, Dept Anesthesiol, Chicago, IL 60611 USA

[3] Santa Casa Fac Med Sao Paulo, Sao Paulo, Brazil

[4] Univ Estadual Paulista, Botucatu Med Sch, Dept Pathol, Sao Paulo, Brazil

[5] Univ Estadual Paulista, Botucatu Med Sch, Dept Anesthesiol, Sao Paulo, Brazil

来源：

ACTA CIRURGICA BRASILEIRA | 2013年 / 28卷 / 01期

基金：

巴西圣保罗研究基金会;

关键词：

Acute Kidney Injury; Fluid Therapy; Colloids; Hetastarch; Rats; MODEL; RESUSCITATION; BIOMARKER; SURGERY; FLUID; NGAL;

D O I：

10.1590/S0102-86502013000100002

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

PURPOSE: To compare fluid replacement therapy with Hydroxyethyl starch 6% (HES) versus Ringer's lactate (RL) in a rodent model of non-septic renal ischemia. METHODS: Forty male Wistar rats were randomized to receive HES 2 ml. kg(-1).hr(-1) or RL 5 ml. kg(-1).hr(-1) that underwent 30 minutes of renal ischemia followed by reperfusion. Twelve hours after kidney ischemia, the kidneys were evaluated for histological changes. Serum NGAL levels were obtained at different times of the experimental protocol. RESULTS: Rodents in the HES group had a median (IQR) grade of renal injury 3 (3 to 5) compared to 2 (2 to 4) in the RL group (p=0.03). NGAL levels were not associated with the severity of kidney injury. CONCLUSION: Hydroxyethyl starch administration caused more kidney injury than Ringer's lactate in a non-infectious model of renal hypoperfusion.

引用

页码：5 / 9

页数：5

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