The use of shear stress for targeted drug delivery

被引：66

作者：

Saxer, Till ^{[1
]}

Zumbuehl, Andreas ^{[2
]}

Mueller, Bert ^{[3
]}

机构：

[1] Univ Hosp Geneva, Geneva, Switzerland

[2] Univ Fribourg, Dept Chem, CH-1700 Fribourg, Switzerland

[3] Univ Basel, Biomat Sci Ctr BMC, Basel, Switzerland

来源：

CARDIOVASCULAR RESEARCH | 2013年 / 99卷 / 02期

基金：

瑞士国家科学基金会;

关键词：

Targeted drug delivery; Nano medicine; Atherosclerosis; Liposome; Shear stress; VASCULAR-LESIONS; BLOOD-FLOW; ARTERIOSCLEROSIS; ATHEROSCLEROSIS; DOXORUBICIN; DEFINITION; LIPOSOMES; COMMITTEE; COUNCIL; CANCER;

D O I：

10.1093/cvr/cvt102

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Stenosed segments of arteries significantly alter the blood flow known from healthy vessels. In particular, the wall shear stress at critically stenosed arteries is at least an order of magnitude higher than in healthy situations. This alteration represents a change in physical force and might be used as a trigger signal for drug delivery. Mechano-sensitive drug delivery systems that preferentially release their payload under increased shear stress are discussed. Therefore, besides biological or chemical markers, physical triggers are a further principle approach for targeted drug delivery. We hypothesize that such a physical trigger is much more powerful to release drugs for vasodilation, plaque stabilization, or clot lysis at stenosed arteries than any known biological or chemical ones.

引用

页码：328 / 333

页数：6

共 57 条

[1]

Adler-Moore P.J., 1993, J LIPOSOME RES, V3, P429

[2] Sex differences in major bleeding with glycoprotein IIb/IIIa inhibitors - Results from the CRUSADE (can rapid risk stratification of unstable angina patients suppress adverse outcomes with early implementation of the ACC/AHA guidelines) initiative [J].