Comparison of Conservative Treatment and Thymectomy on Myasthenia Gravis Outcome

被引：22
作者：
Taioli, Emanuela
Paschal, Philip Kent
Liu, Bian
Kaufman, Andrew J.
Flores, Raja M.
机构：
[1] Icahn Sch Med Mt Sinai, Dept Populat Hlth Sci & Policy, Thorac Surg, New York, NY 10029 USA
[2] Icahn Sch Med Mt Sinai, Inst Translat Epidemiol, New York, NY 10029 USA
[3] NYU, Coll Arts & Sci, New York, NY USA
来源：
ANNALS OF THORACIC SURGERY | 2016年 / 102卷 / 06期
关键词：
TERM-FOLLOW-UP; PROGNOSTIC-FACTORS; METAANALYSIS; EXPERIENCE; THYMOMA;
D O I：
10.1016/j.athoracsur.2016.08.052
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Background. A systematic review of the literature was performed to compare long-term outcomes of thymectomy and medical treatment for generalized myasthenia gravis (MG). Methods. A Medline search through June 2015 resulted in 71 studies, 27 of which were selected (10,140 patients: 5,275 thymectomies, 4,865 medication). Results. The pooled proportion of remission with thymectomy was 0.31 (95% CI, 0.25-0.37), with conservative treatment it was 0.15 (95% CI, 0.12-0.18). The odds ratio (OR) of remission with thymectomy in comparison with medication alone was 2.44 (95% CI, 1.91-3.12) overall and according to medication type and remission definitions. Conclusions. Thymectomy is superior to conservative treatment with solely medication on remission in MG. (C) 2016 by The Society of Thoracic Surgeons
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收藏
页码：1805 / 1813
页数：9
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