Pharmacokinetic evaluation of almotriptan for the treatment of migraines

被引：6
作者：
Negro, Andrea [1 ,2 ]
Lionetto, Luana [3 ]
D'Alonzo, Lidia [1 ,2 ]
Casolla, Barbara [3 ]
Marsibilio, Francesco [1 ,2 ]
Vignaroli, Gabriele [3 ]
Simmaco, Maurizio [3 ]
Martelletti, Paolo [1 ,2 ]
机构：
[1] Univ Roma La Sapienza, I-00189 Rome, Italy
[2] St Andrea Hosp, Reg Referral Headache Ctr, Dept Clin & Mol Med, Rome, Italy
[3] Univ Roma La Sapienza, St Andrea Hosp, NESMOS Dept, Adv Mol Biol Unit, I-00189 Rome, Italy
来源：
EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY | 2013年 / 9卷 / 05期
关键词：
almotriptan; migraine; pharmacodynamics; pharmacokinetics; triptans; ANTIMIGRAINE AGENT ALMOTRIPTAN; DOUBLE-BLIND; EARLY INTERVENTION; ORAL ALMOTRIPTAN; LONG-TERM; 12.5; MG; CONSISTENT EFFICACY; 5-HT1B/1D AGONISTS; GLOBAL BURDEN; TOLERABILITY;
D O I：
10.1517/17425255.2013.783012
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Introduction: Migraine is a multifactorial neurovascular disorder characterized by recurrent episodes of disabling pain attacks, accompanied with gastrointestinal, neurological systems dysfunction. The pharmacologic treatment of migraine is classically divided in the management of the acute attack and preventive strategies. Triptans represent a powerful pharmacological tool in acute migraine treatment. However, a significant portion of treated patients cannot have access to this class due to possible adverse affects. Today, a total of seven triptan molecules are available, representing a commonly prescribed migraine treatment. Areas covered: The authors take a systematic approach to discuss the pharmacodynamic and pharmacokinetic aspects of almotriptan. They consider the emerging data on the clinical efficacy in the treatment of migraine and menstrual-related migraine. The data were obtained by searching the following key words in MEDLINE: pharmacokinetic, pharmacodynamic, triptans, almotriptan, migraine, menstrual migraine, relatively to the period 1989 - 2012. Expert opinion: The excellent efficacy and superior tolerability profile of almotriptan administered early offer a potential improvement over existing triptans for the symptomatic treatment of migraine attacks. Compared with other triptans, the different pathways involved in the metabolism of almotriptan ensure a limited variability of clinical response to the drug, making it less susceptible to the individual genomic background.
引用
收藏
页码：637 / 644
页数：8
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