Rupture of multiple receptor-ligand bonds: Bimodal distribution of bond rupture force

被引：3
作者：
Gupta, V. K. [1 ]
机构：
[1] Univ Maryland Baltimore Cty, Baltimore, MD 21250 USA
来源：
EUROPEAN PHYSICAL JOURNAL E | 2012年 / 35卷 / 09期
关键词：
L-SELECTIN; ENERGY LANDSCAPES; P-SELECTIN; SPECTROSCOPY MEASUREMENTS; MOLECULAR-MECHANICS; BINDING-KINETICS; ADHESION BONDS; CELL-ADHESION; FLOW; DISSOCIATION;
D O I：
10.1140/epje/i2012-12094-9
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
Monte Carlo simulation of the rupture of multiple receptor-ligand bonds between two PMN cells suspended in a Newtonian fluid is performed. In the presence of a hydrodynamic drag force acting on two PMN cells the interplay of multiple receptor-ligand bonds between these cells leads to a bimodal distribution of the bond rupture force at certain loading rates. Specifically, it is found that the interplay of multiple bonds between two PMN cells in the presence of hydrodynamic drag force acting on these cells modifies the bond energy landscape in such a way as to lead to a bimodal distribution of the bond rupture force where a low force peak switches to a high force peak as the loading rate is increased progressively, characteristics of two-state systems.
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页数：8
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共 46 条
[11]   Dynamic strength of molecular adhesion bonds [J].
Evans, E ;
Ritchie, K .
BIOPHYSICAL JOURNAL, 1997, 72 (04) :1541-1555
[12]  
Evans E, 1998, FARADAY DISCUSS, V111, P1
[13]   Chemically distinct transition states govern rapid dissociation of single L-selectin bonds under force [J].
Evans, E ;
Leung, A ;
Hammer, D ;
Simon, S .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (07) :3784-3789
[14]  
Evans E., 2002, PHYS BIOMOLECULES CE, P145, DOI DOI 10.1007/3-540-45701-1_4
[15]   Force-mediated kinetics of single P-selectin ligand complexes observed by atomic force microscopy [J].
Fritz, J ;
Katopodis, AG ;
Kolbinger, F ;
Anselmetti, D .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (21) :12283-12288
[16]   Vascular adhesion molecules in atherosclerosis [J].
Galkina, Elena ;
Ley, Klaus .
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2007, 27 (11) :2292-2301
[17]   Simultaneous tether extraction from endothelial cells and leukocytes: Observation, mechanics, and significance [J].
Girdhar, Gaurav ;
Shao, Jin-Yu .
BIOPHYSICAL JOURNAL, 2007, 93 (11) :4041-4052
[18]   Magnetic tweezers: Micromanipulation and force measurement at the molecular level [J].
Gosse, C ;
Croquette, V .
BIOPHYSICAL JOURNAL, 2002, 82 (06) :3314-3329
[19]   Effects of multiple-bond ruptures in force spectroscopy measurements of interactions between fullerene C60 molecules in water [J].
Gu, Chao ;
Kirkpatrick, Andrea ;
Ray, Chad ;
Guo, Senli ;
Akhremitchev, Boris B. .
JOURNAL OF PHYSICAL CHEMISTRY C, 2008, 112 (13) :5085-5092
[20]   Effects of multiple-bond ruptures on kinetic parameters extracted from force spectroscopy measurements: Revisiting biotin-streptavidin interactions [J].
Guo, Senli ;
Ray, Chad ;
Kirkpatrick, Andrea ;
Lad, Nimit ;
Akhremitchev, Boris B. .
BIOPHYSICAL JOURNAL, 2008, 95 (08) :3964-3976
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