Sibling rivalry in the E2F family

被引：953
作者：
Trimarchi, JM [1 ]
Lees, JA [1 ]
机构：
[1] MIT, Ctr Canc Res, Cambridge, MA 02139 USA
来源：
NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2002年 / 3卷 / 01期
关键词：
D O I：
10.1038/nrm714
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The E2F transcription factor family determines whether or not a cell will divide by controlling the expression of key cell-cycle regulators. The individual E2Fs can be divided into distinct subgroups that act in direct opposition to one another to promote either cellular proliferation or cell-cycle exit and terminal differentiation. What is the underlying molecular basis of this 'push-me-pull-you' regulation, and what are its biological consequences?
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页码：11 / 20
页数：10
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