Dose-response relationship for risk of non-vertebral fracture with inhaled corticosteroids

被引：63

作者：

Weatherall, M. ^{[2
]}

James, K. ^{[1
]}

Clay, J. ^{[1
]}

Perrin, K. ^{[1
]}

Masoli, M. ^{[1
]}

Wijesinghe, M. ^{[1
]}

Beasley, R. ^{[1
,3
]}

机构：

[1] Med Res Inst, Wellington 6143, New Zealand

[2] Univ Otago, Wellington, New Zealand

[3] Univ Southampton, Southampton, Hants, England

来源：

CLINICAL AND EXPERIMENTAL ALLERGY | 2008年 / 38卷 / 09期

关键词：

adults; asthma; dose-response; fracture; inhaled corticosteroids;

D O I：

10.1111/j.1365-2222.2008.03029.x

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Objective To determine the strength of association between the dose of inhaled corticosteroids (ICS) and risk of non-vertebral fracture in adults. Methods A systematic review and meta-analysis of case-control studies of non-vertebral fractures in adults, in which at least two doses of ICS were reported as the dose of beclomethasone dipropionate (BDP) or equivalent. Results Five case-control studies were identified, with a total of 43 783 cases and 259 936 controls. There was an association between the risk of non-vertebral fracture and increasing dose of BDP. The random-effects odds ratio of relative risk for a non-vertebral fracture was 1.12 (95% confidence interval 1.00-1.26) per 1000 mu g increase in the daily dose of BDP or equivalent. Conclusion In older adults, the relative risk of non-vertebral fractures increases by about 12% for each 1000 mu g/day increase in the dose of BDP or equivalent. The magnitude of this risk was considerably less than other common risk factors for fracture in the older adult.

引用

页码：1451 / 1458

页数：8

共 40 条

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