Leukemoid reaction secondary to hypersensitivity syndrome to phenobarbital: a case report

被引:0
作者
Zeng, Qinghai [1 ]
Wu, Yuanqiang [1 ]
Zhan, Yi [1 ]
Tang, Ling [1 ]
Zhou, Yangmei [1 ]
Yin, Jun [2 ]
Fan, Fan
Zhang, Guiying [1 ]
Lu, Qianjin [1 ]
Xiao, Rong [1 ]
机构
[1] Cent S Univ, Xiangya Hosp 2, Dept Dermatovenereol, Changsha 410011, Hunan, Peoples R China
[2] Cent S Univ, Xiangya Hosp, Dept Neurol, Changsha 410011, Hunan, Peoples R China
来源
INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY | 2013年 / 6卷 / 01期
关键词
Phenobarbital; hypersensitivity syndrome; leukemoid reaction; ANTIEPILEPTIC DRUGS; SYSTEMIC SYMPTOMS; DRESS-SYNDROME; EOSINOPHILIA; ERYTHRODERMA; DIAGNOSIS;
D O I
暂无
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
The most important adverse effects of phenobarbital, an anticonvulsant drug, are behavior and cognitive alterations. Hypersensitivity syndrome caused by phenobarbital presenting with a leukemoid reaction is a rare side effect, which is rarely ever reported and needs to be known. We report on a 27-year-old Chinese woman who experienced hypersensitivity syndrome three weeks after the initiation of phenobarbital. The patient developed fever, skin rash, face swelling, lymphadenopathy, myalgia, hepatitis, eosinophilia, atypical lymphocytes and leukocytosis. Along with the pathological progress of the disease, the patient noticed a gradual exacerbation of her symptoms. And the highest leukocyte count was up to 127.2 x 10(9)/L. After discontinuing of phenobarbital and administration of methylprednisolone combined with the intravenous immunoglobulin shock therapy, all initial symptoms improved and the leukocyte count normalized. This case is reported because of its rarity of the leukemoid reaction secondary to hypersensitivity syndrome to phenobarbital.
引用
收藏
页码:100 / 104
页数:5
相关论文
共 22 条
  • [1] Anticonvulsant hypersensitivity syndrome: Lymphocyte toxicity assay for the confirmation of diagnosis and risk assessment
    Bavdekar, SB
    Muranjan, MN
    Gogtay, NJ
    Kantharia, V
    Kshirsagar, NA
    [J]. ANNALS OF PHARMACOTHERAPY, 2004, 38 (10) : 1648 - 1650
  • [2] Drug hypersensitivity syndrome: DRESS (Drug Reaction with Eosinophilia and Systemic Symptoms)
    Begon, E
    Roujeau, JC
    [J]. ANNALES DE DERMATOLOGIE ET DE VENEREOLOGIE, 2004, 131 (03): : 293 - 297
  • [3] Bota Robert G, 2011, Perm J, V15, P80
  • [4] Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS)/Drug-Induced Hypersensitivity Syndrome (DIHS): a review of current concepts
    Criado, Paulo Ricardo
    Jardim Criado, Roberta Fachini
    Avancini, Joao de Magalhaes
    Santi, Claudia Giuli
    [J]. ANAIS BRASILEIROS DE DERMATOLOGIA, 2012, 87 (03) : 435 - 449
  • [5] Anticonvulsant Hypersensitivity Syndrome Treated With Intravenous Immunoglobulin
    Dredge, David C.
    Parsons, Elizabeth C.
    Carter, Lindsay P.
    Staley, Kevin J.
    [J]. PEDIATRIC NEUROLOGY, 2010, 43 (01) : 65 - 69
  • [6] Antiepileptic Drugs
    Gelisse, Philippe
    Crespel, Arielle
    Genton, Pierre
    [J]. THERAPIE, 2008, 63 (06): : 425 - 451
  • [7] Drug hypersensitivity to previously tolerated phenytoin by carbamazepine-induced DRESS syndrome
    Kim, Cheol-Woo
    Choi, Gwang-Seong
    Yun, Chang-Ho
    Kim, Deok-In
    [J]. JOURNAL OF KOREAN MEDICAL SCIENCE, 2006, 21 (04) : 768 - 772
  • [8] Anticonvulsant hypersensitivity syndrome: an update
    Knowles, Sandra R.
    Dewhurst, Norman
    Shear, Neil H.
    [J]. EXPERT OPINION ON DRUG SAFETY, 2012, 11 (05) : 767 - 778
  • [9] Krauss Gregory, 2006, Epilepsy Curr, V6, P33, DOI 10.1111/j.1535-7511.2006.00089.x
  • [10] KRUMBHAAR E. B., 1926, AMER JOUR MED SCI, V172, P519, DOI 10.1097/00000441-192610000-00005