The vasohibin family: a novel family for angiogenesis regulation

被引：97
作者：
Sato, Yasufumi [1 ]
机构：
[1] Tohoku Univ, Inst Dev Aging & Canc, Dept Vasc Biol, Aoba Ku, Sendai, Miyagi 9808575, Japan
来源：
JOURNAL OF BIOCHEMISTRY | 2013年 / 153卷 / 01期
关键词：
angiogenesis; endothelial cell; SVBP; vasohibin-1; vasohibin-2; NEGATIVE FEEDBACK REGULATOR; PREVENTS TUMOR ANGIOGENESIS; EXPRESSION; ENDOTHELIUM; INHIBITOR; NEOVASCULARIZATION; GROWTH; VEGF;
D O I：
10.1093/jb/mvs128
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Angiogenesis, a formation of neovessels, is regulated by the local balance between angiogenesis stimulators and inhibitors. A number of such endogenous regulators of angiogenesis have been found in the body. Recently, vasohibin-1 (VASH1) was isolated as a negative feedback regulator of angiogenesis produced by endothelial cells (ECs) and subsequently vasohibin-2 (VASH2) as a homologue of VASH1. It was then explored that VASH1 is expressed in ECs to terminate angiogenesis, whereas VASH2 is expressed in cells other than ECs to promote angiogenesis in the mouse model of angiogenesis. This review will focus on the vasohibin family members, which are novel regulators of angiogenesis.
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收藏
页码：5 / 11
页数：7
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