Solution thermodynamics of acetaminophen in some PEG 400+water mixtures

被引：42

作者：

Ahumada, Edgar A. ^{[1
]}

Delgado, Daniel R. ^{[1
]}

Martinez, Fleming ^{[1
]}

机构：

[1] Univ Nacl Colombia, Fac Ciencias, Dept Farm, Grp Invest Farmaceut Fisicoquim, Bogota 14490, DC, Colombia

来源：

FLUID PHASE EQUILIBRIA | 2012年 / 332卷

关键词：

Acetaminophen; Solubility; PEG 400+water mixtures; Solution thermodynamics; WATER COSOLVENT MIXTURES; ENTHALPY-ENTROPY COMPENSATION; SOLUBILITY; ACETANILIDE; PARACETAMOL; DERIVATIVES; SOLVATION;

D O I：

10.1016/j.fluid.2012.07.004

中图分类号：

O414.1 [热力学];

学科分类号：

摘要：

According to the van't Hoff and Gibbs equations, the thermodynamic functions Gibbs energy, enthalpy, and entropy of solution of acetaminophen (ACP) in some PEG 400 + water mixtures were evaluated from drug solubility values determined at several temperatures. By using values of the thermodynamic properties of fusion and sublimation of ACP, the thermodynamic quantities of mixing and solvation were also calculated. By means of enthalpy-entropy compensation analysis, a non-linear Delta H-soln degrees vs. Delta(soln)G degrees compensation plot with negative and positive slopes was obtained considering the entire composition interval, indicating entropy-driving in water-rich mixtures and enthalpy-driving in PEG 400-rich mixtures. (C) 2012 Elsevier B.V. All rights reserved.

引用

页码：120 / 127

页数：8

共 29 条

[11] Solution Thermodynamics of Ketoprofen in Ethanol plus Water Cosolvent Mixtures [J].

Gantiva, Mauricio ;

Yurquina, Alicia ;

Martinez, Fleming .

JOURNAL OF CHEMICAL AND ENGINEERING DATA, 2010, 55 (01) :113-118

[12]

Hildebrand JH, 1970, Regular and related solutions

[13]

the solubility of gases, liquids and solids, DOI DOI 10.1016/S0006-4971(20)78019-5

[14] Solution thermodynamics of indomethacin in propylene glycol plus water mixtures [J].

Holguin, Andres R. ;

Rodriguez, Gerson A. ;

Cristancho, Diana M. ;

Delgado, Daniel R. ;

Martinez, Fleming .

FLUID PHASE EQUILIBRIA, 2012, 314 :134-139

[15] Thermodynamic study of the solubility of acetaminophen in propylene glycol plus water cosolvent mixtures [J].

Jiménez, JA ;

Martínez, F .

JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY, 2006, 17 (01) :125-134

[16]

Jimenez JA., 2006, Revista De La Acad Colombiana De Ciencias Exactas Fisicas Y Naturales, V30, P87, DOI [10.18257/raccefyn.30(114).2006.2217, DOI 10.18257/RACCEFYN.30(114).2006.2217]

[17]

Jouyban A, 2010, HANDBOOK OF SOLUBILITY DATA FOR PHARMACEUTICALS, P1

[18] THERMODYNAMIC INVESTIGATION OF THE EFFECT OF OCTANOL WATER MUTUAL MISCIBILITY ON THE PARTITIONING AND SOLUBILITY OF SOME GUANINE DERIVATIVES [J].

KRISTL, A ;

VESNAVER, G .

JOURNAL OF THE CHEMICAL SOCIETY-FARADAY TRANSACTIONS, 1995, 91 (06) :995-998

[19] ENTHALPY-ENTROPY COMPENSATION .2. SEPARATION OF CHEMICAL FROM STATISTICAL EFFECT [J].

KRUG, RR ;

HUNTER, WG ;

GRIEGER, RA .

JOURNAL OF PHYSICAL CHEMISTRY, 1976, 80 (21) :2341-2351

[20]

Martin A., 1993, Physical pharmacy: physical chemical principles in the pharmaceutical sciences

← 1 2 3 →