Solution thermodynamics of acetaminophen in some PEG 400+water mixtures

被引：42

作者：

Ahumada, Edgar A. ^{[1
]}

Delgado, Daniel R. ^{[1
]}

Martinez, Fleming ^{[1
]}

机构：

[1] Univ Nacl Colombia, Fac Ciencias, Dept Farm, Grp Invest Farmaceut Fisicoquim, Bogota 14490, DC, Colombia

来源：

FLUID PHASE EQUILIBRIA | 2012年 / 332卷

关键词：

Acetaminophen; Solubility; PEG 400+water mixtures; Solution thermodynamics; WATER COSOLVENT MIXTURES; ENTHALPY-ENTROPY COMPENSATION; SOLUBILITY; ACETANILIDE; PARACETAMOL; DERIVATIVES; SOLVATION;

D O I：

10.1016/j.fluid.2012.07.004

中图分类号：

O414.1 [热力学];

学科分类号：

摘要：

According to the van't Hoff and Gibbs equations, the thermodynamic functions Gibbs energy, enthalpy, and entropy of solution of acetaminophen (ACP) in some PEG 400 + water mixtures were evaluated from drug solubility values determined at several temperatures. By using values of the thermodynamic properties of fusion and sublimation of ACP, the thermodynamic quantities of mixing and solvation were also calculated. By means of enthalpy-entropy compensation analysis, a non-linear Delta H-soln degrees vs. Delta(soln)G degrees compensation plot with negative and positive slopes was obtained considering the entire composition interval, indicating entropy-driving in water-rich mixtures and enthalpy-driving in PEG 400-rich mixtures. (C) 2012 Elsevier B.V. All rights reserved.

引用

页码：120 / 127

页数：8

共 29 条

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