Mesoporous carbon nanomaterials in drug delivery and biomedical application

被引：146

作者：

Zhao, Qinfu ^{[1
]}

Lin, Yuanzhe ^{[1
]}

Han, Ning ^{[2
]}

Li, Xian ^{[1
]}

Geng, Hongjian ^{[1
]}

Wang, Xiudan ^{[1
]}

Cui, Yu ^{[1
]}

Wang, Siling ^{[1
]}

机构：

[1] Shenyang Pharmaceut Univ, Sch Pharm, Dept Pharmaceut, Shenyang, Liaoning, Peoples R China

[2] Beijing Univ Chinese Med, Sch Chinese Mat Med, Dept Chinese Med Pharmaceut, Beijing, Peoples R China

来源：

DRUG DELIVERY | 2017年 / 24卷 / 02期

基金：

中国国家自然科学基金;

关键词：

Mesoporous carbon nanomaterials; biocompatibility; drug delivery systems; photothermal therapy; biomedical applications; WATER-SOLUBLE DRUG; ACIDIC TUMOR MICROENVIRONMENT; CHEMO-PHOTOTHERMAL THERAPY; MULTIDRUG-RESISTANCE; SILICA NANOPARTICLES; ORAL BIOAVAILABILITY; CONTROLLED-RELEASE; GRAPHENE OXIDE; P-GLYCOPROTEIN; IN-VITRO;

D O I：

10.1080/10717544.2017.1399300

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Recent development of nano-technology provides highly efficient and versatile treatment methods to achieve better therapeutic efficacy and lower side effects of malignant cancer. The exploration of drug delivery systems (DDSs) based on nano-material shows great promise in translating nano-technology to clinical use to benefit patients. As an emerging inorganic nanomaterial, mesoporous carbon nanomaterials (MCNs) possess both the mesoporous structure and the carbonaceous composition, endowing them with superior nature compared with mesoporous silica nanomaterials and other carbon-based materials, such as carbon nanotube, graphene and fullerene. In this review, we highlighted the cutting-edge progress of carbon nanomaterials as drug delivery systems (DDSs), including immediate/sustained drug delivery systems and controlled/targeted drug delivery systems. In addition, several representative biomedical applications of mesoporous carbon such as (1) photo-chemo synergistic therapy; (2) delivery of therapeutic biomolecule and (3) in vivo bioimaging are discussed and integrated. Finally, potential challenges and outlook for future development of mesoporous carbon in biomedical fields have been discussed in detail.

引用

页码：94 / 107

页数：14

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