The birth of the Epitranscriptome: deciphering the function of RNA modifications

被引：350
作者：
Saletore, Yogesh [1 ,2 ,3 ]
Meyer, Kate [4 ]
Korlach, Jonas [5 ]
Vilfan, Igor D. [5 ]
Jaffrey, Samie [4 ]
Mason, Christopher E. [1 ,2 ]
机构：
[1] Weill Cornell Med Coll, Dept Physiol & Biophys, New York, NY 10065 USA
[2] Weill Cornell Med Coll, HRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsau, New York, NY 10065 USA
[3] Triinst Training Program Computat Biol & Med, New York, NY 10065 USA
[4] Weill Cornell Med Coll, Dept Pharmacol, New York, NY 10065 USA
[5] Pacific Biosci, Menlo Pk, CA 94025 USA
来源：
GENOME BIOLOGY | 2012年 / 13卷 / 10期
基金：
美国国家卫生研究院;
关键词：
epigenetics; epigenomics; epitranscriptome; m(6)A; methyl-6-adenosine; methyladenosine; N6-methyladenosine; RNA modifications; CELL MESSENGER-RNA; NUCLEOTIDE-SEQUENCE; NUCLEAR-RNA; DROSOPHILA-MELANOGASTER; RIBONUCLEIC-ACID; SINGLE-MOLECULE; GENE-EXPRESSION; DNA; METHYLATION; GENOME;
D O I：
10.1186/gb-2012-13-10-175
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Recent studies have found methyl-6-adenosine in thousands of mammalian genes, and this modification is most pronounced near the beginning of the 3'UTR. We present a perspective on current work and new single-molecule sequencing methods for detecting RNA base modifications.
引用
收藏
页数：11
相关论文
共 50 条
  • [41] RNA modifications and cancer
    Haruehanroengra, Phensinee
    Zheng, Ya Ying
    Zhou, Yubin
    Huang, Yun
    Sheng, Jia
    RNA BIOLOGY, 2020, 17 (11) : 1560 - 1575
  • [42] The hidden RNA code: implications of the RNA epitranscriptome in the context of viral infections
    Ribeiro, Diana Roberta
    Nunes, Alexandre
    Ribeiro, Daniela
    Soares, Ana Raquel
    FRONTIERS IN GENETICS, 2023, 14
  • [43] The crosstalk between RNA m6A epitranscriptome and TGFβ signaling pathway contributes to the arrest of cell cycle
    Li, Le
    Chen, Yong-Xian
    Yang, Bing
    Liao, Jian-You
    Peng, Jing-Wen
    Zhu, Shuang
    GENE, 2020, 738
  • [44] The emerging biology of RNA post-transcriptional modifications
    Nachtergaele, Sigrid
    He, Chuan
    RNA BIOLOGY, 2017, 14 (02) : 156 - 163
  • [45] RNA Modifications in Pathogenic Viruses: Existence, Mechanism, and Impacts
    Zou, Yingying
    Guo, Zhoule
    Ge, Xing-Yi
    Qiu, Ye
    MICROORGANISMS, 2024, 12 (11)
  • [46] Epitranscriptome marks detection and localization of RNA modifying proteins in mammalian ovarian follicles
    Dubuc, Karine
    Marchais, Mathilde
    Gilbert, Isabelle
    Bastien, Alexandre
    Nenonene, Karen E.
    Khandjian, Edward W.
    Viger, Robert S.
    Delbes, Geraldine
    Robert, Claude
    JOURNAL OF OVARIAN RESEARCH, 2023, 16 (01)
  • [47] Small RNA modifications: regulatory molecules and potential applications
    Xiong, Qunli
    Zhang, Yaguang
    JOURNAL OF HEMATOLOGY & ONCOLOGY, 2023, 16 (01)
  • [48] The m6A epitranscriptome: transcriptome plasticity in brain development and function
    Livneh, Ido
    Moshitch-Moshkovitz, Sharon
    Amariglio, Ninette
    Rechavi, Gideon
    Dominissini, Dan
    NATURE REVIEWS NEUROSCIENCE, 2020, 21 (01) : 36 - 51
  • [49] The epitranscriptome in modulating spatiotemporal RNA translation in neuronal post-synaptic function
    Hussain, Shobbir
    Bashir, Zafar I.
    FRONTIERS IN CELLULAR NEUROSCIENCE, 2015, 9
  • [50] RNA modifications in pulmonary diseases
    Qian, Weiwei
    Yang, Lvying
    Li, Tianlong
    Li, Wanlin
    Zhou, Jian
    Xie, Shenglong
    MEDCOMM, 2024, 5 (05):
12345