The birth of the Epitranscriptome: deciphering the function of RNA modifications

被引：350
作者：
Saletore, Yogesh [1 ,2 ,3 ]
Meyer, Kate [4 ]
Korlach, Jonas [5 ]
Vilfan, Igor D. [5 ]
Jaffrey, Samie [4 ]
Mason, Christopher E. [1 ,2 ]
机构：
[1] Weill Cornell Med Coll, Dept Physiol & Biophys, New York, NY 10065 USA
[2] Weill Cornell Med Coll, HRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsau, New York, NY 10065 USA
[3] Triinst Training Program Computat Biol & Med, New York, NY 10065 USA
[4] Weill Cornell Med Coll, Dept Pharmacol, New York, NY 10065 USA
[5] Pacific Biosci, Menlo Pk, CA 94025 USA
来源：
GENOME BIOLOGY | 2012年 / 13卷 / 10期
基金：
美国国家卫生研究院;
关键词：
epigenetics; epigenomics; epitranscriptome; m(6)A; methyl-6-adenosine; methyladenosine; N6-methyladenosine; RNA modifications; CELL MESSENGER-RNA; NUCLEOTIDE-SEQUENCE; NUCLEAR-RNA; DROSOPHILA-MELANOGASTER; RIBONUCLEIC-ACID; SINGLE-MOLECULE; GENE-EXPRESSION; DNA; METHYLATION; GENOME;
D O I：
10.1186/gb-2012-13-10-175
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Recent studies have found methyl-6-adenosine in thousands of mammalian genes, and this modification is most pronounced near the beginning of the 3'UTR. We present a perspective on current work and new single-molecule sequencing methods for detecting RNA base modifications.
引用
收藏
页数：11
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