The birth of the Epitranscriptome: deciphering the function of RNA modifications

被引：350

作者：

Saletore, Yogesh ^{[1
,2
,3
]}

Meyer, Kate ^{[4
]}

Korlach, Jonas ^{[5
]}

Vilfan, Igor D. ^{[5
]}

Jaffrey, Samie ^{[4
]}

Mason, Christopher E. ^{[1
,2
]}

机构：

[1] Weill Cornell Med Coll, Dept Physiol & Biophys, New York, NY 10065 USA

[2] Weill Cornell Med Coll, HRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsau, New York, NY 10065 USA

[3] Triinst Training Program Computat Biol & Med, New York, NY 10065 USA

[4] Weill Cornell Med Coll, Dept Pharmacol, New York, NY 10065 USA

[5] Pacific Biosci, Menlo Pk, CA 94025 USA

来源：

GENOME BIOLOGY | 2012年 / 13卷 / 10期

基金：

美国国家卫生研究院;

关键词：

epigenetics; epigenomics; epitranscriptome; m(6)A; methyl-6-adenosine; methyladenosine; N6-methyladenosine; RNA modifications; CELL MESSENGER-RNA; NUCLEOTIDE-SEQUENCE; NUCLEAR-RNA; DROSOPHILA-MELANOGASTER; RIBONUCLEIC-ACID; SINGLE-MOLECULE; GENE-EXPRESSION; DNA; METHYLATION; GENOME;

D O I：

10.1186/gb-2012-13-10-175

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Recent studies have found methyl-6-adenosine in thousands of mammalian genes, and this modification is most pronounced near the beginning of the 3'UTR. We present a perspective on current work and new single-molecule sequencing methods for detecting RNA base modifications.

引用

页数：11

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