A convenient and mild chromatography-free method for the purification of the products of Wittig and Appel reactions

被引：79

作者：

Byrne, Peter A. ^{[1
]}

Rajendran, Kamalraj V. ^{[1
]}

Muldoon, Jimmy ^{[1
]}

Gilheany, Declan G. ^{[1
]}

机构：

[1] Univ Coll Dublin, Sch Chem & Chem Biol, Ctr Synth & Chem Biol, Dublin 4, Ireland

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2012年 / 10卷 / 17期

基金：

爱尔兰科学基金会;

关键词：

PHOSPHINE OXIDES; PHOSPHONIUM SALTS; SOLID-STATE; REDUCTION; REAGENT; STEREOSELECTIVITY; TRIPHENYLPHOSPHINE; STEREOCHEMISTRY; TRANSFORMATION; MECHANISM;

D O I：

10.1039/c2ob07074j

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A mild method for the facile removal of phosphine oxide from the crude products of Wittig and Appel reactions is described. Work-up with oxalyl chloride to generate insoluble chlorophosphonium salt (CPS) yields phosphorus-free products for a wide variety of these reactions. The CPS product can be further converted into phosphine.

引用

页码：3531 / 3537

页数：7

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