A convenient and mild chromatography-free method for the purification of the products of Wittig and Appel reactions

被引：76
作者：
Byrne, Peter A. [1 ]
Rajendran, Kamalraj V. [1 ]
Muldoon, Jimmy [1 ]
Gilheany, Declan G. [1 ]
机构：
[1] Univ Coll Dublin, Sch Chem & Chem Biol, Ctr Synth & Chem Biol, Dublin 4, Ireland
来源：
ORGANIC & BIOMOLECULAR CHEMISTRY | 2012年 / 10卷 / 17期
基金：
爱尔兰科学基金会;
关键词：
PHOSPHINE OXIDES; PHOSPHONIUM SALTS; SOLID-STATE; REDUCTION; REAGENT; STEREOSELECTIVITY; TRIPHENYLPHOSPHINE; STEREOCHEMISTRY; TRANSFORMATION; MECHANISM;
D O I：
10.1039/c2ob07074j
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A mild method for the facile removal of phosphine oxide from the crude products of Wittig and Appel reactions is described. Work-up with oxalyl chloride to generate insoluble chlorophosphonium salt (CPS) yields phosphorus-free products for a wide variety of these reactions. The CPS product can be further converted into phosphine.
引用
收藏
页码：3531 / 3537
页数：7
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