HAM/TSP: association between white matter lesions on magnetic resonance imaging, clinical and cerebrospinal fluid findings

被引：24

作者：

Puccioni-Sohler, Marzia ^{[1
,2
]}

Gasparetto, Emerson ^{[3
]}

Cabral-Castro, Mauro Jorge ^{[4
,5
]}

Slatter, Carla ^{[6
]}

Vidal, Cecilia M. ^{[6
]}

Cortes, Romeu Domingues ^{[7
]}

Rosen, Bruce R. ^{[8
]}

Mainero, Caterina

机构：

[1] Fed Univ Rio de Janeiro HUCFF UFRJ, Clin Pathol Serv, Cerebrospinal Fluid Lab, Univ Hosp Clementino Fraga Filho, Rio De Janeiro, RJ, Brazil

[2] Fed Univ State Rio de Janeiro HUGG UNIRIO, Neurolife & Neuroinfect Clin, Cerebrospinal Fluid Lab, Univ Hosp Graffree & Guinle, Rio De Janeiro, RJ, Brazil

[3] Ctr Imaging Diag CDPI, Rio De Janeiro, RJ, Brazil

[4] HUCFF UFRJ, Clin Pathol Serv, Cerebrospinal Fluid Lab, Rio De Janeiro, RJ, Brazil

[5] UFRJ, Inst Microbiol Paulo de Goes, Rio De Janeiro, RJ, Brazil

[6] HUGG UNIRIO, Neuroinfect Clin, Rio De Janeiro, RJ, Brazil

[7] CDPI, Rio De Janeiro, RJ, Brazil

[8] Harvard Univ, Sch Med, Athinoula A Martinos Ctr, Boston, MA USA

来源：

ARQUIVOS DE NEURO-PSIQUIATRIA | 2012年 / 70卷 / 04期

基金：

美国国家卫生研究院;

关键词：

human T-lymphotropic virus 1; HTLV-1 associated myelopathy; cerebrospinal fluid; magnetic resonance imaging; I-ASSOCIATED MYELOPATHY; VIRUS TYPE-I; TROPICAL SPASTIC PARAPARESIS; T-LYMPHOTROPIC VIRUS; CENTRAL-NERVOUS-SYSTEM; HTLV-I; MULTIPLE-SCLEROSIS; MRI; BRAIN; ANTIBODIES;

D O I：

10.1590/S0004-282X2012000400004

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Objective: To investigate the association between clinical data,white matter lesions and inflammatory cerebrospinal fluid (CSF) findings in HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP). Method: We studied brain and cervical spinal cord on magnetic resonance imaging (MRI) and CSF examinations of 28 Brazilian HAM/TSP patients. Results: The majority of patients had severe neurological incapacity with EDSS median of 6.5 (3-8). The brain MRI showed white matter lesions (75%) and atrophy (14%). The preferential brain location was periventricutar. Cervical demyelination lesions occurred in 11% of the cases, and cervical atrophy in 3.5%. One patient had enhancement lesions on T1 cervical spinal cord MRI. Cases with spinal cord lesions had signs of acute CSF inflammation. The brain white matter lesions predominated in the patients with higher age. Conclusion: Our data suggest that an active inflammatory process is associated with the cervical spinal cord lesions in HAM/TSP. The brain abnormalities are not related to the clinical picture of HAM/TSP.

引用

页码：246 / 251

页数：6

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