Involvement of spinal monocyte chemoattractant protein-1 (MCP-1) in cancer-induced bone pain in rats

被引：58
作者：
Hu, Ji-Hua [1 ]
Zheng, Xiao-Yan [1 ]
Yang, Jian-Ping [1 ]
Wang, Li-Na [1 ]
Ji, Fu-Hai [1 ]
机构：
[1] Soochow Univ, Affiliated Hosp 1, Dept Anesthesiol, Suzhou 215006, Jiangsu, Peoples R China
来源：
NEUROSCIENCE LETTERS | 2012年 / 517卷 / 01期
关键词：
Cancer induced bone pain; MCP-1; CCR2; Chemokine; Rat; PERIPHERAL-NERVE INJURY; NEUROPATHIC PAIN; CHEMOKINE RECEPTOR; SENSORY NEURONS; EXPRESSION; CORD; CCR2; MODEL; ACTIVATION; CCL2;
D O I：
10.1016/j.neulet.2012.04.026
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
In this study, we examined the involvement of chemokine monocyte chemoattractant protein-1 (MCP-1) in the spinal cord of a rat model of cancer-induced bone pain (CIBP). In this model. CIBP was established by an intramedullary injection of Walker 256 cells into the tibia of rats. We observed a significant increase in expression levels of MCP-1 and its receptor CCR2 in the spinal cord of CIBP rats. Furthermore, the intrathecal administration of an anti-MCP-1 neutralizing antibody attenuated the mechanical allodynia established in CIBP rats. Likewise, an intrathecal injection of exogenous recombinant MCP-1 induced a striking mechanical allodynia in naive rats. These results suggest that increases in spinal MCP-1 and CCR2 expression are involved in the development of mechanical allodynia associated with bone cancer rats. (c) 2012 Elsevier Ireland Ltd. All rights reserved.
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收藏
页码：60 / 63
页数：4
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