Involvement of spinal monocyte chemoattractant protein-1 (MCP-1) in cancer-induced bone pain in rats

被引：59

作者：

Hu, Ji-Hua ^{[1
]}

Zheng, Xiao-Yan ^{[1
]}

Yang, Jian-Ping ^{[1
]}

Wang, Li-Na ^{[1
]}

Ji, Fu-Hai ^{[1
]}

机构：

[1] Soochow Univ, Affiliated Hosp 1, Dept Anesthesiol, Suzhou 215006, Jiangsu, Peoples R China

来源：

NEUROSCIENCE LETTERS | 2012年 / 517卷 / 01期

关键词：

Cancer induced bone pain; MCP-1; CCR2; Chemokine; Rat; PERIPHERAL-NERVE INJURY; NEUROPATHIC PAIN; CHEMOKINE RECEPTOR; SENSORY NEURONS; EXPRESSION; CORD; CCR2; MODEL; ACTIVATION; CCL2;

D O I：

10.1016/j.neulet.2012.04.026

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

In this study, we examined the involvement of chemokine monocyte chemoattractant protein-1 (MCP-1) in the spinal cord of a rat model of cancer-induced bone pain (CIBP). In this model. CIBP was established by an intramedullary injection of Walker 256 cells into the tibia of rats. We observed a significant increase in expression levels of MCP-1 and its receptor CCR2 in the spinal cord of CIBP rats. Furthermore, the intrathecal administration of an anti-MCP-1 neutralizing antibody attenuated the mechanical allodynia established in CIBP rats. Likewise, an intrathecal injection of exogenous recombinant MCP-1 induced a striking mechanical allodynia in naive rats. These results suggest that increases in spinal MCP-1 and CCR2 expression are involved in the development of mechanical allodynia associated with bone cancer rats. (c) 2012 Elsevier Ireland Ltd. All rights reserved.

引用

页码：60 / 63

页数：4

共 27 条

[1] Impaired neuropathic pain responses in mice lacking the chemokine receptor CCR2 [J].

Abbadie, C ;

Lindia, JA ;

Cumiskey, AM ;

Peterson, LB ;

Mudgett, JS ;

Bayne, EK ;

DeMartino, JA ;

MacIntyre, DE ;

Forrest, MJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (13) :7947-7952

[2] Chemokines and pain mechanisms [J].

Abbadie, Catherine ;

Bhangoo, Sonia ;

De Koninck, Yves ;

Malcangio, Marzia ;

Melik-Parsadaniantz, Stephane ;

White, Fletcher A. .

BRAIN RESEARCH REVIEWS, 2009, 60 (01) :125-134

[3] Cultured rat microglia express functional β-chemokine receptors [J].

Boddeke, EWGM ;

Meigel, I ;

Frentzel, S ;

Gourmala, NG ;

Harrison, JK ;

Buttini, M ;

Spleiss, O ;

Gebicke-Härter, P .

JOURNAL OF NEUROIMMUNOLOGY, 1999, 98 (02) :176-184

[4] QUANTITATIVE ASSESSMENT OF TACTILE ALLODYNIA IN THE RAT PAW [J].

CHAPLAN, SR ;

BACH, FW ;

POGREL, JW ;

CHUNG, JM ;

YAKSH, TL .

JOURNAL OF NEUROSCIENCE METHODS, 1994, 53 (01) :55-63

[5] Spinal CCL2 pronociceptive action is no longer effective in CCR2 receptor antagonist-treated rats [J].

Dansereau, Marc-Andre ;

Gosselin, Romain-Daniel ;

Pohl, Michel ;

Pommier, Blandine ;

Mechighel, Patricia ;

Mauborgne, Annie ;

Rostene, William ;

Kitabgi, Patrick ;

Beaudet, Nicolas ;

Sarret, Philippe ;

Melik-Parsadaniantz, Stephane .

JOURNAL OF NEUROCHEMISTRY, 2008, 106 (02) :757-769

[6] JNK-Induced MCP-1 Production in Spinal Cord Astrocytes Contributes to Central Sensitization and Neuropathic Pain [J].

Gao, Yong-Jing ;

Zhang, Ling ;

Samad, Omar Abdel ;

Suter, Marc R. ;

Yasuhiko, Kawasaki ;

Xu, Zhen-Zhong ;

Park, Jong-Yeon ;

Lind, Anne-Li ;

Ma, Qiufu ;

Ji, Ru-Rong .

JOURNAL OF NEUROSCIENCE, 2009, 29 (13) :4096-4108

[7] Constitutive expression of CCR2 chemokine receptor and inhibition by MCP-1/CCL2 of GABA-induced currents in spinal cord neurones [J].

Gosselin, RD ;

Varela, C ;

Banisadr, G ;

Mechighel, P ;

Rostene, W ;

Kitabgi, P ;

Melik-Parsadaniantz, S .

JOURNAL OF NEUROCHEMISTRY, 2005, 95 (04) :1023-1034

[8] Murine models of inflammatory, neuropathic and cancer pain each generates a unique set of neurochemical changes in the spinal cord and sensory neurons [J].

Honore, P ;

Rogers, SD ;

Schwei, MJ ;

Salak-Johnson, JL ;

Luger, NM ;

Sabino, MC ;

Clohisy, DR ;

Mantyh, PW .

NEUROSCIENCE, 2000, 98 (03) :585-598

[9] EXPRESSION OF MONOCYTE CHEMOATTRACTANT PROTEIN-1 AND ITS INDUCTION BY TUMOR NECROSIS FACTOR RECEPTOR 1 IN SENSORY NEURONS IN THE VENTRAL RHIZOTOMY MODEL OF NEUROPATHIC PAIN [J].

Jeon, S. -M. ;

Sung, J. -K. ;

Cho, H. -J. .

NEUROSCIENCE, 2011, 190 :354-366

[10] Visualization of Chemokine Receptor Activation in Transgenic Mice Reveals Peripheral Activation of CCR2 Receptors in States of Neuropathic Pain [J].

Jung, Hosung ;

Bhangoo, Sonia ;

Banisadr, Ghazal ;

Freitag, Caroline ;

Ren, Dongjun ;

White, Fletcher A. ;

Miller, Richard J. .

JOURNAL OF NEUROSCIENCE, 2009, 29 (25) :8051-8062

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