The 'complexities' of life and death: Death receptor signalling platforms

被引：156
作者：
Dickens, Laura S. [1 ]
Powley, Ian R. [1 ]
Hughes, Michelle A. [1 ]
MacFarlane, Marion [1 ]
机构：
[1] Univ Leicester, MRC Toxicol Unit, Leicester LE1 9HN, Leics, England
来源：
EXPERIMENTAL CELL RESEARCH | 2012年 / 318卷 / 11期
基金：
英国医学研究理事会;
关键词：
Apoptosis; Necroptosis; DISC; FADD; Caspase-8; RIPK; cFLIP; NF-KAPPA-B; APOPTOSIS-INDUCING LIGAND; CELL-DEATH; CASPASE-8; ACTIVATION; TNF RECEPTOR; PROGRAMMED NECROSIS; SELECTIVE MUTANTS; DOMAIN PROTEIN; CFLIP ISOFORMS; T-CELLS;
D O I：
10.1016/j.yexcr.2012.04.005
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Cell death is critical to the normal functioning of multi-cellular organisms, playing a central role in development, immunity, inflammation, and cancer progression. Two cell death mechanisms, apoptosis and necroptosis, are dependent on the formation of distinct multi-protein complexes including the DISC, Apoptosome, Piddosome and Necrosome following the induction of cell death by specific stimuli. The role of several of these key multi-protein signalling platforms, namely the DISC, TNFR1 complex I/II, the Necrosome and Ripoptosome, in mediating these pathways will be discussed, as well as the open questions and potential therapeutic benefits of understanding their underlying mechanisms. (C) 2012 Elsevier Inc. All rights reserved.
引用
收藏
页码：1269 / 1277
页数：9
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