Chronic hepatitis E in a heart transplant patient: sofosbuvir and ribavirin regimen not fully effective

被引：23

作者：

Todesco, Eve ^{[1
,2
]}

Mazzola, Alessandra ^{[3
]}

Akhavan, Sepideh ^{[2
,4
]}

Abravanel, Florence ^{[5
,6
]}

Poynard, Thierry ^{[7
,8
,9
]}

Roque-Afonso, Anne-Marie ^{[10
]}

Peytavin, Gilles ^{[11
,12
]}

Marcelin, Anne-Genevieve ^{[1
,2
]}

Calmus, Yvon ^{[3
]}

Lecuyer, Lucien ^{[13
]}

Guillemain, Romain ^{[14
]}

Conti, Filomena ^{[3
]}

机构：

[1] UPMC Univ Paris 06, Sorbonne Univ, INSERM, IPLESP,UMRS 1136, Paris, France

[2] Hop La Pitie Salpetriere, AP HP, Dept Virol, Paris, France

[3] UPMC Paris VI, Hop Pitie Salpetriere, AP HP, Unite Med Transplantat Hepat,Hepatogastroenterol, Blvd Hop, Paris, France

[4] UPMC Univ Paris 06, Sorbonne Univ, CIMI Paris UMRS CR7, PVI Team,Inserm,U1135, Paris, France

[5] CHU Toulouse, Hop Purpan, Lab Virol, Natl Reference Ctr Hepatitis E, Toulouse, France

[6] INSERM, Ctr Physiopathol Toulouse Purpan, U1043, Toulouse, France

[7] Grp Hosp Pitie Salpetriere, AP HP, Paris, France

[8] UPMC Univ Paris 06, Sorbonne Univ, UMR S 938, Paris, France

[9] INSERM, Inst Cardiometab & Nutr ICAN, Paris, France

[10] Univ Paris Sud, Hop Paul Brousse, AP HP, INSERM,Virol,U1193, Villejuif, France

[11] Bichat Claude Bernard Hosp, AP HP, Pharmacotoxicol Dept, Paris, France

[12] Univ Paris Diderot, Sorbonne Paris Cite, IAME, INSERM,UMR 1137, Paris, France

[13] Univ Paris 05, Hop Europeen Georges Pompidou, AP HP, Serv Chirurg Cardiovasc, Paris, France

[14] Hop Europeen Georges Pompidou, AP HP, Pole Cardiovasc Nephrol Hypertens Diabet, Unite Fonct Transplantat Thorac, Paris, France

来源：

ANTIVIRAL THERAPY | 2018年 / 23卷 / 05期

关键词：

E VIRAL-INFECTION; REPLICATION;

D O I：

10.3851/IMP3227

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Hepatitis E virus (HEV) can induce chronic infections in the case of immunosuppression, which are sometimes not cured with ribavirin. Furthermore, sofosbuvir is a highly potent inhibitor of HCV polymerase and was shown to inhibit HEV genotype-3 replication in vitro. We report here the outcome of sofosbuvir/ribavirin therapy on a chronic HEV infection in a heart transplant recipient non-responder to ribavirin. After 24 weeks, the regimen failed to cure the persistent HEV infection, highlighting the need of therapeutic options for HEV-infected immunosuppressed patients.

引用

页码：463 / 465

页数：3

共 12 条

[1] A Mutation in the Hepatitis E Virus RNA Polymerase Promotes Its Replication and Associates With Ribavirin Treatment Failure in Organ Transplant Recipients [J].