Total Synthesis of Penostatin B

被引：34

作者：

Fujioka, Kosuke ^{[1
]}

Yokoe, Hiromasa ^{[1
]}

Yoshida, Masahiro ^{[1
]}

Shishido, Kozo ^{[1
]}

机构：

[1] Univ Tokushima, Grad Sch Pharmaceut Sci, Tokushima 7708505, Japan

来源：

ORGANIC LETTERS | 2012年 / 14卷 / 01期

关键词：

ALPHA; BETA-UNSATURATED CARBONYL-COMPOUNDS; CYTOTOXIC METABOLITES; CYCLIZATIONS; LACTONES; FRAGMENT; STRATEGY; HYDRIDE;

D O I：

10.1021/ol203021c

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The first total synthesis of penostatin B has been accomplished by using a highly diastereoselective Pauson-Khand reaction and an efficient relay ring-closing metathesis for the construction of the basic carbon skeleton of the natural product as the key steps.

引用

页码：244 / 247

页数：4

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