Association of estrogen receptor-beta (ESR2) polymorphism and cancer risk: a meta-analysis

被引：4

作者：

Xia, Wenkai ^{[1
]}

Wang, Tianyi ^{[2
]}

Sun, Dong ^{[1
]}

Mao, Weidong ^{[3
]}

Xie, Xiangcheng

机构：

[1] Southeast Univ, Coll Med, Affiliated Jiangyin Hosp, Dept Nephrol, Wuxi, Peoples R China

[2] Yangzhou Univ Med, Yangzhou, Jiangsu, Peoples R China

[3] Jiangyin Peoples Hosp, Dept Oncol, Jiangyin, Peoples R China

来源：

EUROPEAN JOURNAL OF GYNAECOLOGICAL ONCOLOGY | 2016年 / 37卷 / 04期

关键词：

ESR2; Polymorphism; Cancer risk; Meta-analysis; PROSTATE-CANCER; BREAST-CANCER; GENETIC POLYMORPHISMS; ENDOMETRIAL CANCER; PROMOTER REGION; OPPOSING ROLES; OVARIAN-CANCER; LUNG-CANCER; WOMEN; SUSCEPTIBILITY;

D O I：

10.12892/ejgo3014.2016

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Estrogen signal medicated by estrogen receptor (ER), which is involved in various diseases related to steroid hormone, such as cancer. A number of association studies have focused on ESR2 polymorphisms to investigate the relationship with cancer risk. However, the results are inconsistent and inconclusive. To examine this controversy, 33 studies were enrolled for the pooled analysis for three polymorphisms (rs3020450, rs4986938, and rs1256049) in cancer risk using odds ratios (ORs) with 95% confidence intervals (CIs). Regarding rs4986938, A allele was associated with decreased breast cancer. Ethnicity subgroup analysis observed a decreased risk in both Asian and Caucasian descendent. Regarding rs1256049, cancer type subgroup analysis revealed a significant association with increased prostate and endometrial cancer risk. rs3020450 was not associated with cancer risk in any model. Further studies for clarifying the roles of ESR2 polymorphisms in cancer risk seem of vital importance.

引用

页码：530 / 538

页数：9

共 46 条

[1]

[Anonymous], 2010, INT J CANCER, V126, P2935

[2] Estrogen receptor polymorphisms and the risk of endometrial cancer [J].

Ashton, K. A. ;

Proietto, A. ;

Otton, G. ;

Symonds, I. ;

McEvoy, M. ;

Attia, J. ;

Gilbert, M. ;

Hamann, U. ;

Scott, R. J. .

BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY, 2009, 116 (08) :1053-1061

[3] Genetic Polymorphisms of Estrogen Receptors α and β and the Risk of Developing Prostate Cancer [J].

Chae, Young Kwang ;

Huang, Han-Yao ;

Strickland, Paul ;

Hoffman, Sandra C. ;

Helzlsouer, Kathy .

PLOS ONE, 2009, 4 (08)

[4] Sequence variants of estrogen receptor β and risk of prostate cancer in the national cancer institute breast and prostate cancer cohort consortium [J].

Chen, Yen-Ching ;

Kraft, Peter ;

Bretsky, Philip ;

Ketkar, Shamika ;

Hunter, David J. ;

Albanes, Demetrius ;

Altshuler, David ;

Andriole, Gerald ;

Berg, Christine D. ;

Boeing, Heiner ;

Burtt, Noel ;

Bueno-de-Mesquita, Bas ;

Cann, Howard ;

Canzian, Federico ;

Chanock, Stephen ;

Dunning, Alison ;

Feigelson, Heather S. ;

Freedman, Matthew ;

Gaziano, J. Michael ;

Giovannucci, Edward ;

Sanchez, Maria-Jose ;

Haiman, Christopher A. ;

Hallmans, Goran ;

Hayes, Richard B. ;

Henderson, Brian E. ;

Hirschhorn, Joel ;

Kaaks, Rudolf ;

Key, Timothy J. ;

Kolonel, Laurence N. ;

LeMarchand, Loic ;

Ma, Jing ;

Overvad, Kim ;

Palli, Domenico ;

Pharaoh, Paul ;

Pike, Malcolm ;

Riboli, Eliot ;

Rodriguez, Carmen ;

Setiawan, V. Wendy ;

Stampfer, Meir ;

Stram, Daniel O. ;

Thomas, Gilles ;

Thun, Michael J. ;

Travis, Ruth C. ;

Virtamo, Jarmo ;

Trichopouiou, Antonia ;

Wacholder, Sholom ;

Weinstein, Stephanie J. .

CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION, 2007, 16 (10) :1973-1981

[5] Haplotypes of the estrogen receptor beta gene and breast cancer risk [J].

Cox, David G. ;

Bretsky, Philip ;

Kraft, Peter ;

Pharoah, Paul .

INTERNATIONAL JOURNAL OF CANCER, 2008, 122 (02) :387-392

[6] Polymorphisms of Estrogen Receptors: Risk Factors for Invasive Melanoma - A Prospective Study [J].

de Giorgi, Vincenzo ;

Sestini, Serena ;

Gori, Alessia ;

Mazzotta, Celestina ;

Grazzini, Marta ;

Rossari, Susanna ;

Mavilia, Carmelo ;

Crocetti, Emanuele ;

Brandi, Maria Luisa ;

Lotti, Torello ;

Massi, Daniela .

ONCOLOGY, 2011, 80 (3-4) :232-237

[7] Estrogen Receptors β1 and β2 Have Opposing Roles in Regulating Proliferation and Bone Metastasis Genes in the Prostate Cancer Cell Line PC3 [J].

Dey, Prasenjit ;

Jonsson, Philip ;

Hartman, Johan ;

Williams, Cecilia ;

Stroem, Anders ;

Gustafsson, Jan-Ake .

MOLECULAR ENDOCRINOLOGY, 2012, 26 (12) :1991-2003

[8] Trim and fill: A simple funnel-plot-based method of testing and adjusting for publication bias in meta-analysis [J].

Duval, S ;

Tweedie, R .

BIOMETRICS, 2000, 56 (02) :455-463

[9]

Eastwood H, 2002, MOL PSYCHIATR, V7, P86

[10] The Dual, Opposing Roles of Estrogen in the Prostate [J].

Ellem, Stuart J. ;

Risbridger, Gail P. .

STEROID ENZYMES AND CANCER, 2009, 1155 :174-186

← 1 2 3 4 5 →