Spectral detection of micro-metastases in lymph node histo-pathology

被引：25

作者：

Bird, Benjamin ^{[1
]}

Romeo, Melissa ^{[1
]}

Laver, Nora ^{[2
]}

Diem, Max ^{[1
]}

机构：

[1] Northeastern Univ, Lab Spectral Diag, Dept Chem & Chem Biol, Boston, MA 02115 USA

[2] Tufts Univ, Tufts Med Ctr, Dept Pathol, Boston, MA 02111 USA

来源：

JOURNAL OF BIOPHOTONICS | 2009年 / 2卷 / 1-2期

关键词：

Infrared Spectral Imaging; breast cancer micro-metastases; multivariate analysis; hierarchical cluster analysis; spectral diagnosis;

D O I：

10.1002/jbio.200810066

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

The first detection of breast cancer micrometastases in lymph nodes by infrared spectral imaging and methods of multivariate analysis is reported. Micrometastases are indicators of early spread of cancer from the organ originally affected by disease, and their detection is of prime importance for the staging and treatment of cancer. Infrared spectral imaging, at a spatial resolution of ca. 10-12 mu m, can detect small metastases down to the level of a few cancerous cells. The results presented here add to a rapidly growing database of infrared spectral imaging results for cancer diagnostics.

引用

页码：37 / 46

页数：10

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