DNA-associated click chemistry

被引：31

作者：

Haque, Mohammad Mojibul ^{[1
]}

Peng XiaoHua ^{[1
]}

机构：

[1] Univ Wisconsin Milwaukee, Dept Chem & Biochem, Milwaukee, WI 53211 USA

来源：

SCIENCE CHINA-CHEMISTRY | 2014年 / 57卷 / 02期

关键词：

click" chemistry; oligodeoxynucleotides; DNA functionalization; DNA ligation and cross-linking; AZIDE-ALKYNE CYCLOADDITION; LINKED OLIGONUCLEOTIDES; SOLID-PHASE; LIGATION; PROTEIN; FUNCTIONALIZATION; CONSTRUCTION; FLUORESCENCE; BIOCONJUGATION; NUCLEOSIDE;

D O I：

10.1007/s11426-013-5035-1

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

This review highlights the most recent advances in click chemistry associated with DNA. Cu[I]-catalyzed azides-alkynes Huisgen cycloadditions (CuAAC) and a strain-promoted alkyne-azide cycloaddition (SPAAC) are two popular click reactions that have great impact in DNA science. The simplicity, versatility, orthogonality, and high efficiency of click reaction along with a stable triazole product have been instrumental for the successful application of this reaction in the field of nucleic acid chemistry. CuAAC and SPAAC reactions have been widely used for DNA modification, including DNA labeling, metallization, conjugation, cross-linking, and ligation. Modified oligodeoxynucleotides obtained from click reaction have been extensively applied in the fields of drug discovery, nanotechnology, bio-conjugation, and material sciences, among others. The most recent advances in the synthesis and applications of clickable DNAs are discussed in detail in this article.

引用

页码：215 / 231

页数：17

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