Exome Variant Analysis of Chronic Periodontitis in 2 Large Cohort Studies

被引：6

作者：

Kasbohm, E. ^{[1
]}

Holtfreter, B. ^{[1
]}

Volker, U. ^{[2
]}

Petersmann, A. ^{[3
]}

Samietz, S. ^{[4
]}

Biffar, R. ^{[4
]}

Voelzke, H. ^{[5
]}

Meisel, P. ^{[1
]}

Kacprowski, T. ^{[2
]}

Homuth, G. ^{[2
]}

Kocher, T. ^{[1
]}

Teumer, A. ^{[5
]}

机构：

[1] Univ Med Greifswald, Unit Periodontol, Dept Restorat Dent Periodontol & Endodontol Pedod, Greifswald, Germany

[2] Univ Med Greifswald, Dept Funct Genom, Interfac Inst Genet & Funct Genom, Greifswald, Germany

[3] Univ Med Greifswald, Inst Clin Chem & Lab Med, Greifswald, Germany

[4] Univ Med Greifswald, Ctr Oral Hlth, Dept Prosthodont Gerostomatol & Biomat, Greifswald, Germany

[5] Univ Med Greifswald, Inst Community Med, Greifswald, Germany

来源：

JOURNAL OF DENTAL RESEARCH | 2017年 / 96卷 / 01期

关键词：

genetic association studies; periodontal attachment loss; genetic variation; medical genetics; periodontal diseases; genetic markers; GENOME-WIDE ASSOCIATION; MISSING HERITABILITY; GERMAN POPULATION; RARE VARIANTS; DISEASES; HEALTH; POMERANIA;

D O I：

10.1177/0022034516665076

中图分类号：

R78 [口腔科学];

学科分类号：

1003 ;

摘要：

Periodontitis is characterized by inflammation of the gingival tissue. The main risk factors are socioeconomic factors, sex, age, smoking, and diabetes, but periodontal disease has also a genetic background. Previous genome-wide association studies failed to reveal genome-wide significant associations of single common single-nucleotide polymorphisms with chronic periodontitis. Using the Illumina ExomeChip data of 6,576 participants of the German population-based cohort studies Study of Health in Pomerania (SHIP) and SHIP-Trend, the authors performed single variant and also gene-based association studies of rare and common exonic variations on different periodontal case definitions. Although our study comprised the largest sample size to date to assess genetic predisposition for chronic periodontitis, the authors found no significant association. This study emphasizes that for chronic periodontitis, large sample sizes will be necessary to find genetic associations, even when examining rare genetic variants.

引用

页码：73 / 80

页数：8

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