Bisphosphonate therapy for unresectable symptomatic benign bone tumors: A long-term prospective study of tolerance and efficacy

被引:53
作者
Cornelis, F. [1 ]
Truchetet, M. E. [2 ]
Amoretti, N. [3 ]
Verdier, D. [1 ]
Fournier, C. [1 ]
Pillet, O. [4 ]
Gille, O. [5 ]
Hauger, O. [1 ]
机构
[1] Pellegrin Hosp, Dept Radiol, F-33076 Bordeaux, France
[2] Pellegrin Hosp, Dept Rheumatol, F-33076 Bordeaux, France
[3] CHU Nice, Hop Archet 2, Dept Radiol, F-06202 Nice, France
[4] Pediat Hosp, Dept Pediat, F-33076 Bordeaux, France
[5] Pellegrin Hosp, Dept Orthoped Surg, F-33076 Bordeaux, France
关键词
Bone tumor; Bisphosphonate; Tolerance; GIANT-CELL TUMOR; ZOLEDRONIC ACID; SKELETAL METASTASES; OSTEOLYTIC LESIONS; HISTIOCYTOSIS; OSTEONECROSIS; PAMIDRONATE; CANCER; JAWS; CT;
D O I
10.1016/j.bone.2013.10.004
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Objectives: To evaluate the long-term tolerance of bisphosphonates proposed as an alternative therapeutic option for symptomatic unresectable benign bone tumors and to evaluate the long-term efficacy of this treatment. Methods: From March 2007 to March 2011, patients with unresectable symptomatic benign bone tumors were consecutively included in this institutional review board-approved study and treated with bisphosphonates. Prospectively long-term follow-up is reported. The study endpoints were to describe the long-term tolerance, the clinical evolution of pain for each patient and the radiological success defined as a complete disappearance of inflammation and ossification of the bone lesion. All complications and side effects were recorded. Results: Eight patients (mean age 16 years; range 7-42) with various tumor subtypes were included: aneurysmal bone cysts (N = 5), Langerhans cell histiocytosis (N = 1), osteoblastoma (N = 1), and a giant cell tumor (N = 1). Tumors were located in cervical (N = 4) or thoracic (N = 1) vertebrae, femoral shaft (N = 1), acetabulum (N = 1) and sacrum (N = 1). Mean number of bisphosphonate cycles was 3 (range: 1-6) over a median period of 10 months. The median clinical and imaging follow-up period was 21 months (6 to 63 months). No severe complications due to treatment or lesion recurrence were reported. Pain disappeared within 6 weeks of the first cycle for all but one patient. Ossification of the bone lesion was observed for all patients but one, complete for two and partial for the five others. Conclusions: Bisphosphonates appear to be an effective option without adverse effects for the non-operative management of symptomatic benign bone tumors. (C) 2013 Elsevier Inc. All rights reserved.
引用
收藏
页码:11 / 16
页数:6
相关论文
共 23 条
[1]   Pamidronate for bone pain from osteolytic lesions in Langerhans'-cell histiocytosis [J].
Arzoo, K ;
Sadeghi, S ;
Pullarkat, V .
NEW ENGLAND JOURNAL OF MEDICINE, 2001, 345 (03) :225-225
[2]   Osteonecrosis of the jaw in cancer after treatment with bisphosphonates: Incidence and risk factors [J].
Bamias, A ;
Kastritis, E ;
Bamia, C ;
Moulopoulos, LA ;
Melakopoulos, L ;
Bozas, G ;
Koutsoukou, V ;
Gika, D ;
Anagnostopoulos, A ;
Papadimitriou, C ;
Terpos, E ;
Dimopoulos, MA .
JOURNAL OF CLINICAL ONCOLOGY, 2005, 23 (34) :8580-8587
[3]  
Bisdas S, 2008, CLIN RADIOL, V63, P71, DOI 10.1016/j.crad.2007.04.023
[4]   Denosumab Induces Tumor Reduction and Bone Formation in Patients with Giant-Cell Tumor of Bone [J].
Branstetter, Daniel G. ;
Nelson, Scott D. ;
Manivel, J. Carlos ;
Blay, Jean-Yves ;
Chawla, Sant ;
Thomas, David M. ;
Jun, Susie ;
Jacobs, Ira .
CLINICAL CANCER RESEARCH, 2012, 18 (16) :4415-4424
[5]   Bisphosphonate Therapy is Effective in the Treatment of Sacral Giant Cell Tumor [J].
Chaudhary, Preeti ;
Khadim, Haider ;
Gajra, Ajeet ;
Damron, Timothy ;
Shah, Chirag .
ONKOLOGIE, 2011, 34 (12) :702-704
[6]   Bisphosphonates induce apoptosis of stromal tumor cells in giant cell tumor of bone [J].
Cheng, YY ;
Huang, L ;
Lee, KM ;
Xu, JK ;
Zheng, MH ;
Kumta, SM .
CALCIFIED TISSUE INTERNATIONAL, 2004, 75 (01) :71-77
[7]   The antitumor potential of bisphosphonates [J].
Clézardin, P .
SEMINARS IN ONCOLOGY, 2002, 29 (06) :33-42
[8]   Treatment of Langerhans cell histiocytosis with pamidronate [J].
Farran, RP ;
Zaretski, E ;
Egeler, RM .
JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY, 2001, 23 (01) :54-56
[9]   Bone-Within-Bone Appearance: A Red Flag for Biphosphonate-Associated Osteonecrosis of the Jaw [J].
Fatterpekar, Girish M. ;
Emmrich, Julius Valentin ;
Eloy, Jean Anderson ;
Aggarwal, Amit .
JOURNAL OF COMPUTER ASSISTED TOMOGRAPHY, 2011, 35 (05) :553-556
[10]   Regression of Giant Cell Tumor of the Cervical Spine With Bisphosphonate as Single Therapy [J].
Gille, Olivier ;
Oliveira, Bruno de Azevedo ;
Guerin, Patrick ;
Lepreux, Sebastien ;
Richez, Christophe ;
Vital, Jean-Marc .
SPINE, 2012, 37 (06) :E396-E399