Immune regulation by CD52-expressing CD4 T cells

被引：18
作者：
Toh, Ban-Hock [1 ]
Kyaw, Tin [1 ,2 ]
Tipping, Peter [1 ]
Bobik, Alex [2 ]
机构：
[1] Monash Univ, Fac Med Nursing & Hlth Sci, Southern Clin Sch, Ctr Inflammatory Dis,Dept Med, Clayton, Vic, Australia
[2] Baker IDI Heart & Diabet Inst, Vasc Biol & Atherosclerosis Lab, Melbourne, Vic, Australia
来源：
CELLULAR & MOLECULAR IMMUNOLOGY | 2013年 / 10卷 / 05期
关键词：
MULTIPLE-SCLEROSIS; AUTOIMMUNE-DISEASES; CD52; ANTIGEN; 4C8; ALEMTUZUMAB; EXPRESSION; SIGLEC-10; TRANSPLANTATION; INDUCTION; CAMPATH-1;
D O I：
10.1038/cmi.2013.35
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
T-cell regulation by CD52-expressing CD4 T cells appears to operate by two different and possibly synergistic mechanisms. The first is by its release from the cell surface of CD4 T cells that express high levels of CD52 that then binds to the inhibitory sialic acid-binding immunoglobulin-like lectins-10 (Siglec-10) receptor to attenuate effector T-cell activation by impairing phosphorylation of T-cell receptor associated lck and zap-70. The second mechanism appears to be by crosslinkage of the CD52 molecules by an as yet unidentified endogenous ligand that is mimicked by a bivalent anti-CD52 antibody that results in their expansion.
引用
收藏
页码：379 / 382
页数：4
相关论文
共 29 条
  • [1] T cell regulation mediated by interaction of soluble CD52 with the inhibitory receptor Siglec-10
    Bandala-Sanchez, Esther
    Zhang, Yuxia
    Reinwald, Simone
    Dromey, James A.
    Lee, Bo-Han
    Qian, Junyan
    Boehmer, Ralph M.
    Harrison, Leonard C.
    [J]. NATURE IMMUNOLOGY, 2013, 14 (07) : 741 - +
  • [2] Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse
    Brunkow, ME
    Jeffery, EW
    Hjerrild, KA
    Paeper, B
    Clark, LB
    Yasayko, SA
    Wilkinson, JE
    Galas, D
    Ziegler, SF
    Ramsdell, F
    [J]. NATURE GENETICS, 2001, 27 (01) : 68 - 73
  • [3] Autoimmune disease after alemtuzumab treatment for multiple sclerosis in a multicenter cohort
    Cossburn, M.
    Pace, A. A.
    Jones, J.
    Ali, R.
    Ingram, G.
    Baker, K.
    Hirst, C.
    Zajicek, J.
    Scolding, N.
    Boggild, M.
    Pickersgill, T.
    Ben-Shlomo, Y.
    Coles, A.
    Robertson, N. P.
    [J]. NEUROLOGY, 2011, 77 (06) : 573 - 579
  • [4] Costelloe L, 2012, EXPERT REV NEUROTHER, V12, P335, DOI [10.1586/ERN.12.5, 10.1586/ern.12.5]
  • [5] N-linked glycan of a sperm CD52 glycoform associated with human infertility
    Diekman, AB
    Norton, EJ
    Klotz, KL
    Westbrook, VA
    Shibahara, H
    Naaby-Hansen, S
    Flickinger, CJ
    Herr, JC
    [J]. FASEB JOURNAL, 1999, 13 (11) : 1303 - 1313
  • [6] Surface and mRNA expression of the CD52 antigen by human eosinophils but not by neutrophils
    Elsner, J
    Hochstetter, R
    Spiekermann, K
    Kapp, A
    [J]. BLOOD, 1996, 88 (12) : 4684 - 4693
  • [7] TNF defined as a therapeutic target for rheumatoid arthritis and other autoimmune diseases
    Feldmann, M
    Maini, RN
    [J]. NATURE MEDICINE, 2003, 9 (10) : 1245 - 1250
  • [8] Interleukin 2 signaling is required for CD4+ regulatory T cell function
    Furtado, GC
    de Lafaille, MAC
    Kutchukhidze, N
    Lafaille, JJ
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 2002, 196 (06) : 851 - 857
  • [9] Coexpression of CD49b and LAG-3 identifies human and mouse T regulatory type 1 cells
    Gagliani, Nicola
    Magnani, Chiara F.
    Huber, Samuel
    Gianolini, Monica E.
    Pala, Mauro
    Licona-Limon, Paula
    Guo, Binggege
    Herbert, De'Broski R.
    Bulfone, Alessandro
    Trentini, Filippo
    Di Serio, Clelia
    Bacchetta, Rosa
    Andreani, Marco
    Brockmann, Leonie
    Gregori, Silvia
    Flavell, Richard A.
    Roncarolo, Maria-Grazia
    [J]. NATURE MEDICINE, 2013, 19 (06) : 739 - +
  • [10] Rediscovering alemtuzumab: current and emerging therapeutic roles
    Gribben, John G.
    Hallek, Michael
    [J]. BRITISH JOURNAL OF HAEMATOLOGY, 2009, 144 (06) : 818 - 831
123