Qigong exercise for the symptoms of Parkinson's disease:: a randomized, controlled pilot study

被引:103
作者
Schmitz-Hübsch, T
Pyfer, D
Kielwein, K
Firnmers, R
Wüllner, U
机构
[1] Univ Bonn, Dept Neurol, D-5300 Bonn, Germany
[2] Med Soc Qigong Yangsheng, Bonn, Germany
[3] Univ Bonn, Inst Med Biometr Informat & Epidemiol, D-5300 Bonn, Germany
关键词
Parkinson's disease; exercise; Qigong; clinical trial;
D O I
10.1002/mds.20705
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Irrespective of limited evidence, not only traditional physiotherapy, but also a wide array of complementary methods are applied by patients with Parkinson's disease (PD). We evaluated the immediate and sustained effects of Qigong on motor and nonmotor symptoms of PD, using an add-on design. Fifty-six patients with different levels of disease severity (mean age/standard deviation [SD], 63.8/7.5 years; disease duration 5.8/4.2 years; 43 men [76%]) were recruited from the outpatient movement disorder clinic of the Department of Neurology, University of Bonn. We compared the progression of motor symptoms assessed by Unified Parkinson's Disease Rating Scale motor part (UPDRS-III) in the Qigong treatment group (n = 32) and a control group receiving no additional intervention (n = 24). Qigong exercises were applied as 90-minute weekly group instructions for 2 months, followed by a 2 months pause and a second 2-month treatment period. Assessments were carried out at baseline, 3, 6, and 12 months. More patients improved in the Qigong group than in the control group at 3 and 6 months (P = 0.0080 at 3 months and P = 0.0503 at 6 months; Fisher's exact test). At 12 months, there was a sustained difference between groups only when changes in UPDRS-III were related to baseline. Depression scores decreased in both groups, whereas the incidence of several nonmotor symptoms decreased in the treatment group only. (C) 2005 Movement Disorder Society.
引用
收藏
页码:543 / 548
页数:6
相关论文
共 28 条
[1]  
[Anonymous], COCHRANE DATABASE SY
[2]   Effects of exercise on cognitive and motor function in chronic fatigue syndrome and depression [J].
Blackwood, SK ;
MacHale, SM ;
Power, MJ ;
Goodwin, GM ;
Lawrie, SM .
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 1998, 65 (04) :541-546
[3]  
Blindauer K, 2003, ARCH NEUROL-CHICAGO, V60, P1721
[4]   Functional imaging studies on dopamine and motor control [J].
Brooks, DJ .
JOURNAL OF NEURAL TRANSMISSION, 2001, 108 (11) :1283-1298
[5]   A case study of simultaneous recovery from multiple physical symptoms with medical qigong therapy [J].
Chen, KW ;
Turner, FD .
JOURNAL OF ALTERNATIVE AND COMPLEMENTARY MEDICINE, 2004, 10 (01) :159-162
[6]   Dopamine release in human ventral striatum and expectation of reward [J].
de la Fuente-Fernández, R ;
Phillips, AG ;
Zamburlini, M ;
Sossi, V ;
Calne, DB ;
Ruth, TJ ;
Stoessl, AJ .
BEHAVIOURAL BRAIN RESEARCH, 2002, 136 (02) :359-363
[7]   MINI-MENTAL STATE - PRACTICAL METHOD FOR GRADING COGNITIVE STATE OF PATIENTS FOR CLINICIAN [J].
FOLSTEIN, MF ;
FOLSTEIN, SE ;
MCHUGH, PR .
JOURNAL OF PSYCHIATRIC RESEARCH, 1975, 12 (03) :189-198
[8]   Multicenter, placebo-controlled trial of cabergoline taken once daily in the treatment of Parkinson's disease [J].
Hutton, JT ;
Koller, WC ;
Ahlskog, JE ;
Pahwa, R ;
Hurtig, HI ;
Stern, MB ;
Hiner, BC ;
Lieberman, A ;
Pfeiffer, RF ;
Rodnitzky, RL ;
Waters, CH ;
Muenter, MD ;
Adler, CH ;
Morris, JL .
NEUROLOGY, 1996, 46 (04) :1062-1065
[9]   Functional decline in Parkinson disease [J].
Jankovic, J ;
Kapadia, AS .
ARCHIVES OF NEUROLOGY, 2001, 58 (10) :1611-1615
[10]   SELF-REPORTED FUNCTIONING AND WELL-BEING IN PATIENTS WITH PARKINSONS-DISEASE - COMPARISON OF THE SHORT-FORM HEALTH SURVEY (SF-36) AND THE PARKINSONS-DISEASE QUESTIONNAIRE (PDQ-39) [J].
JENKINSON, C ;
PETO, V ;
FITZPATRICK, R ;
GREENHALL, R ;
HYMAN, N .
AGE AND AGEING, 1995, 24 (06) :505-509