Does eosinophilia predict clozapine induced neutropenia?

被引：33

作者：

Hummer, M

SpernerUnterweger, B

Kemmler, G

Falk, M

Kurz, M

Oberbauer, H

Fleischhacker, WW

机构：

[1] UNIV INNSBRUCK, DEPT BIOSTAT, A-6020 INNSBRUCK, AUSTRIA

[2] UNIV INNSBRUCK CLIN, DEPT GEN PSYCHIAT, A-6020 INNSBRUCK, AUSTRIA

来源：

PSYCHOPHARMACOLOGY | 1996年 / 124卷 / 1-2期

关键词：

clozapine; haloperidol; eosinophilia; neutropenia; agranulocytosis;

D O I：

10.1007/BF02245622

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The atypical antipsychotic clozapine carries a high risk of inducing agranulocytosis. We attempted to investigate whether eosinophilia during clozapine treatment has predictive value for subsequent neutropenia/agranulocytosis. One hundred and seventy-seven patients were studied in a prospective naturalistic design using haloperidol as the reference compound. Clozapine was found to differ from haloperidol in respect to their influence on neutrophil granulocytes. In the clozapine group patients with eosinophilia showed a decrease in neutrophil count (less than 2000/mm(3) neutrophil granulocytes) significantly more often than patients without eosinophilia.

引用

页码：201 / 204

页数：4

共 24 条

[1] ABT K, 1992, DRUG SAFETY S, V1, P10
[2] CLOZAPINE-INDUCED AGRANULOCYTOSIS - INCIDENCE AND RISK-FACTORS IN THE UNITED-STATES
ALVIR, JMJ
LIEBERMAN, JA
SAFFERMAN, AZ
SCHWIMMER, JL
SCHAAF, JA
[J]. NEW ENGLAND JOURNAL OF MEDICINE, 1993, 329 (03) : 162 - 167
[3] BANOV MD, 1993, J CLIN PSYCHIAT, V54, P466
[4] REGULATION OF MYELOPOIESIS
BENDER, JG
VANEPPS, DE
STEWART, CC
[J]. COMPARATIVE IMMUNOLOGY MICROBIOLOGY AND INFECTIOUS DISEASES, 1987, 10 (02) : 79 - 91
[5] Claas F H, 1992, Drug Saf, V7 Suppl 1, P3
[6] FISCHER V, 1991, MOL PHARMACOL, V40, P846
[7] EOSINOPHILIA, CLOZAPINE, AND PANCREATITIS
FRANKENBURG, FR
KANDO, J
[J]. LANCET, 1992, 340 (8813) : 251 - 251
[8] Gerson S L, 1992, Drug Saf, V7 Suppl 1, P17
[9] HOFFBRAND AV, 1992, DRUG SAFETY S1, V7, P60
[10] HOFFBRAND AV, 1992, DRUG SAFETY S, V1, P57

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