Toxicity of superparamagnetic iron oxide nanoparticles: Research strategies and implications for nanomedicine

被引：38

作者：

Li Lei ^{[1
]}

Jiang Ling-Ling ^{[1
]}

Zeng Yun ^{[1
,2
]}

Liu Gang ^{[1
]}

机构：

[1] Xiamen Univ, Sch Publ Hlth, Ctr Mol Imaging & Translat Med, Xiamen 361102, Peoples R China

[2] North Sichuan Med Coll, Sichuan Key Lab Med Imaging, Nanchong 637007, Peoples R China

来源：

CHINESE PHYSICS B | 2013年 / 22卷 / 12期

基金：

中国国家自然科学基金;

关键词：

superparamagnetic iron oxide nanoparticle; nanotoxicity; cytotoxicity; oxidative stress; reactive oxygen species; MAGNETIC NANOPARTICLES; IN-VIVO; OXIDATIVE STRESS; DRUG-DELIVERY; STEM-CELLS; BIOMEDICAL APPLICATIONS; TISSUE DISTRIBUTION; TARGETED DELIVERY; PROSTATE-CANCER; CONTRAST AGENT;

D O I：

10.1088/1674-1056/22/12/127503

中图分类号：

O4 [物理学];

学科分类号：

0702 ;

摘要：

Superparamagnetic iron oxide nanoparticles (SPIONs) are one of the most versatile and safe nanoparticles in a wide variety of biomedical applications. In the past decades, considerable efforts have been made to investigate the potential adverse biological effects and safety issues associated with SPIONs, which is essential for the development of next-generation SPIONs and for continued progress in translational research. In this mini review, we summarize recent developments in toxicity studies on SPIONs, focusing on the relationship between the physicochemical properties of SPIONs and their induced toxic biological responses for a better toxicological understanding of SPIONs.

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页数：10

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