Omega-3 fatty acids are inversely related to callous and unemotional traits in adolescent boys with attention deficit hyperactivity disorder

被引：23

作者：

Gow, Rachel V. ^{[1
]}

Vallee-Tourangeau, Frederic

Crawford, Michael Angus ^{[2
]}

Taylor, Eric ^{[1
]}

Ghebremeskel, Kebreab ^{[3
]}

Bueno, Allain A. ^{[4
]}

Hibbeln, Joseph R. ^{[5
]}

Sumich, Alexander ^{[6
]}

Rubia, Katya ^{[1
]}

机构：

[1] Kings Coll London, Inst Psychiat, London, England

[2] Univ London Imperial Coll Sci Technol & Med, Div Reprod Physiol Obstet & Gynaecol, London SW7 2AZ, England

[3] London Metropolitan Univ, Lipid & Nutr Res Ctr, London, England

[4] Univ Worcester, Inst Sci & Environm, Worcester, England

[5] NIAAA, Bethesda, MD 20892 USA

[6] Nottingham Trent Univ, Sch Social Sci, Nottingham, England

来源：

PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS | 2013年 / 88卷 / 06期

关键词：

Omega-3 fatty acids; EPA; Callous and unemotional traits; ADHD; ESSENTIAL FATTY-ACIDS; PLACEBO-CONTROLLED TRIAL; YOUNG-ADULT PRISONERS; DEFICIT/HYPERACTIVITY DISORDER; ANTISOCIAL-BEHAVIOR; DOCOSAHEXAENOIC ACID; LINOLENIC ACID; CHILDREN; SUPPLEMENTATION; AGGRESSION;

D O I：

10.1016/j.plefa.2013.03.009

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A number of research studies have reported abnormal plasma fatty acid profiles in children with ADHD along with some benefit of n-3 to symptoms of ADHD. However, it is currently unclear whether (lower) long chain-polyunsaturated fatty acids (LC-PUFAs) are related to ADHD pathology or to associated behaviours. The aim of this study was to test whether (1) ADHD children have abnormal plasma LC-PUFA levels and (2) ADHD symptoms and associated behaviours are correlated with LC-PUFA levels. Seventy-two, male children with (n = 29) and without a clinical diagnosis of ADHD (n = 43) were compared in their plasma levels of LC-PUFA. Plasma DHA was higher in the control group prior to statistical correction. Callous unemotional (CU) traits were found to be significantly negatively related to both eicosapentaenoic acid (EPA), and total omega-3 in the ADHD group. The findings unveil for the first time that CU and anti-social traits in ADHD are associated with lower omega-3 levels. (c) 2013 Elsevier Ltd. All rights reserved.

引用

页码：411 / 418

页数：8

共 51 条

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