Lack of association of apolipoprotein E (Apo E) polymorphism with the prevalence of metabolic syndrome: the National Heart, Lung and Blood Institute Family Heart Study

被引:8
|
作者
Lai, Lana Y. H. [1 ,2 ]
Petrone, Andrew B. [3 ]
Pankow, James S. [4 ]
Arnett, Donna K. [5 ]
North, Kari E. [6 ]
Ellison, R. Curtis [7 ]
Hunt, Steven C. [8 ]
Rosenzweig, James L. [1 ,9 ]
Djousse, Luc [3 ,10 ,11 ]
机构
[1] Boston Univ, Sch Med, Boston, MA 02118 USA
[2] Sarawak Gen Hosp, Clin Res Ctr, Kuching, Malaysia
[3] Brigham & Womens Hosp, Div Aging, Boston, MA 02115 USA
[4] Univ Minnesota, Div Epidemiol & Community Hlth, Minneapolis, MN USA
[5] Univ Alabama Birmingham, Dept Epidemiol, Birmingham, AL USA
[6] Univ N Carolina, Sch Publ Hlth, Dept Epidemiol, Chapel Hill, NC USA
[7] Boston Univ, Sch Med, Prevent Med & Epidemiol Sect, Boston, MA 02118 USA
[8] Univ Utah, Cardiovasc Genet, Salt Lake City, UT USA
[9] Boston Med Ctr, Dept Endocrinol Diabet & Nutr, Boston, MA USA
[10] Harvard Univ, Sch Med, Boston, MA USA
[11] Boston Vet Affairs Healthcare Syst, Boston, MA USA
关键词
apolipoprotein E (Apo E) polymorphism; metabolic syndrome; blood pressure; glucose; dyslipidaemia; high-density lipoprotein cholesterol; CORONARY-ARTERY-DISEASE; C-REACTIVE PROTEIN; MYOCARDIAL-INFARCTION; RISK; GENE; CHOLESTEROL; FREQUENCIES; MORTALITY; SEVERITY; ALLELES;
D O I
10.1002/dmrr.2638
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
ObjectiveMetabolic syndrome (MetS), characterized by abdominal obesity, atherogenic dyslipidaemia, elevated blood pressure and insulin resistance, is a major public health concern in the United States. The effects of apolipoprotein E (Apo E) polymorphism on MetS are not well established. MethodsWe conducted a cross-sectional study consisting of 1551 participants from the National Heart, Lung and Blood Institute Family Heart Study to assess the relation of Apo E polymorphism with the prevalence of MetS. MetS was defined according to the American Heart Association-National Heart, Lung and Blood Institute-International Diabetes Federation-World Health Organization harmonized criteria. We used generalized estimating equations to estimate adjusted odds ratios (ORs) for prevalent MetS and the Bonferroni correction to account for multiple testing in the secondary analysis. ResultsOur study population had a mean age (standard deviation) of 56.5 (11.0) years, and 49.7% had MetS. There was no association between the Apo E genotypes and the MetS. The multivariable adjusted ORs (95% confidence interval) were 1.00 (reference), 1.26 (0.31-5.21), 0.89 (0.62-1.29), 1.13 (0.61-2.10), 1.13 (0.88-1.47) and 1.87 (0.91-3.85) for the ?3/?3, ?2/?2, ?2/?3, ?2/?4, ?3/?4 and ?4/?4 genotypes, respectively. In a secondary analysis, ?2/?3 genotype was associated with 41% lower prevalence odds of low high-density lipoprotein [multivariable adjusted ORs (95% confidence interval)=0.59 (0.36-0.95)] compared with ?3/?3 genotype. ConclusionsOur findings do not support an association between Apo E polymorphism and MetS in a multicentre population-based study of predominantly White US men and women. Copyright (c) 2015 John Wiley & Sons, Ltd.
引用
收藏
页码:582 / 587
页数:6
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