Novel approaches to reactivate pertussis immunity

被引：6
作者：
Blanchard-Rohner, Geraldine [1 ,2 ,3 ]
机构：
[1] Univ Geneva, Fac Med, Ctr Vaccinol, Dept Pathol & Immunol, Geneva, Switzerland
[2] Univ Geneva, Geneva Univ Hosp, Dept Pediat Gynecol & Obstet, Div Gen Pediat,Unit Immunol & Vaccinol, Geneva, Switzerland
[3] Univ Geneva, Fac Med, Ctr Vaccinol, Dept Pathol & Immunol, 6 Rue Willy-Donze 1211 Geneve 14, CH-1211 Geneva, Switzerland
来源：
EXPERT REVIEW OF VACCINES | 2022年 / 21卷 / 12期
关键词：
Bordetella pertussis; vaccine-preventable; vaccine; vaccine effectiveness; neonates; delivery routes; ATTENUATED BORDETELLA-PERTUSSIS; 2 ACELLULAR VACCINES; WHOLE-CELL VACCINE; PROTECTIVE IMMUNITY; IMMUNIZATION; DIPHTHERIA; TETANUS; TOXIN; IMMUNOGENICITY; ADOLESCENTS;
D O I：
10.1080/14760584.2022.2149499
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
IntroductionWhole cell and acellular pertussis vaccines have been very effective in decreasing the deaths of neonates and infants from Bordetella pertussis. Despite high vaccine coverage worldwide, pertussis remains one of the most common vaccine-preventable diseases, thus suggesting that new pertussis vaccination strategies are needed. Several candidates are currently under development, such as acellular pertussis vaccines that use genetically detoxified pertussis toxin, acellular pertussis vaccines delivered with new adjuvants or new delivery systems, or an intranasally delivered, live attenuated vaccine.Areas coveredThis review discusses the different possibilities for improving current pertussis vaccines and the present state of knowledge on the pertussis vaccine candidates under development.Expert opinionUntil there is a safe, effective, and affordable alternative to the two types of existing vaccines, we should maintain sufficient childhood coverage and increase the vaccination of pregnant women, adolescents, and young adults.
引用
收藏
页码：1787 / 1797
页数：11
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