Rhodium(I)-Catalyzed Arylation of β-Chloro Ketones and Related Derivatives through Domino Dehydrochlorination/Conjugate Addition

被引：22

作者：

Jiang, Quanbin ^{[1
]}

Guo, Tenglong ^{[1
]}

Wang, Qingfu ^{[1
]}

Wu, Ping ^{[1
]}

Yu, Zhengkun ^{[1
,2
]}

机构：

[1] Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Liaoning, Peoples R China

[2] Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organometall Chem, Shanghai 200032, Peoples R China

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2013年 / 355卷 / 09期

基金：

中国国家自然科学基金;

关键词：

arylation; beta-chloro ketones; domino reactions; rhodium(I); sp3 CCl bond cleavage; SECONDARY ALKYL CHLORIDES; SUZUKI CROSS-COUPLINGS; C BOND FORMATION; HALIDES; ACIDS; SULFONES; ALCOHOLS; BROMIDES; IODIDES;

D O I：

10.1002/adsc.201200821

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Highly efficient arylations of -chloro ketones and their ester and amide derivatives were achieved by means of domino dehydrochlorination/Rh(I)-catalyzed conjugate addition. In situ generated vinyl ketones and their analogues were identified as the reaction intermediates. The present synthetic protocol provides a concise route to (chiral) -aryl ketones, esters, and amides.

引用

页码：1874 / 1880

页数：7

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