Prevalence of protective antibody against hepatitis B virus in HIV-infected children with immune recovery after highly active antiretroviral therapy

被引：35

作者：

Siriaksorn, S

Puthanakit, T ^{[1
]}

Sirisanthana, T

Sirisanthana, V

机构：

[1] Chiang Mai Univ, Fac Med, Dept Pediat, Div Infect Dis, Chiang Mai 50200, Thailand

[2] Chiang Mai Univ, Res Inst Hlth Sci, Chiang Mai, Thailand

来源：

VACCINE | 2006年 / 24卷 / 16期

关键词：

hepatitis B virus (HBV); human immunodeficiency virus (HIV); protective antibody;

D O I：

10.1016/j.vaccine.2006.01.045

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

HIV-infected children had a lower seroconversion rate to hepatitis B immunization and a more rapid antibody decline when compared to healthy children. Whether re-immunization or additional booster dose is necessary after immune recovery remains unknown. This study was conducted to determine the prevalence of hepatitis B virus protective antibody in HIV-infected children with immune recovery after highly active antiretroviral therapy (HAART). Serum hepatitis B viral markers were measured. An antibody level of > 10 mlU/mL was defined as a protective antibody level. Only one out of 69 children (1%) had a protective antibody level. We concluded that despite the history of hepatitis B immunization and despite evidence of immune recovery after HAART, most HIV-infected children are still susceptible to HBV infection. (c) 2006 Elsevier Ltd. All rights reserved.

引用

页码：3095 / 3099

页数：5

共 22 条

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