Does the Framingham cardiovascular disease risk score also have predictive utility for dementia death? An individual participant meta-analysis of 11,887 men and women

被引：17

作者：

Russ, Tom C. ^{[1
,2
]}

Hamer, Mark ^{[3
]}

Stamatakis, Emmanuel ^{[3
]}

Starr, John M. ^{[1
,2
]}

Batty, G. David ^{[2
,3
]}

Kivimaeki, Mika ^{[3
]}

机构：

[1] Univ Edinburgh, Alzheimer Scotland Dementia Res Ctr, Edinburgh EH8 9JZ, Midlothian, Scotland

[2] Univ Edinburgh, Ctr Cognit Ageing & Cognit Epidemiol, Edinburgh EH8 9JZ, Midlothian, Scotland

[3] UCL, Dept Epidemiol & Publ Hlth, London, England

来源：

ATHEROSCLEROSIS | 2013年 / 228卷 / 01期

基金：

美国国家卫生研究院; 英国医学研究理事会; 英国经济与社会研究理事会; 英国生物技术与生命科学研究理事会; 英国工程与自然科学研究理事会;

关键词：

Framingham study; Risk; Prediction; Mortality; Dementia; Cardiovascular disease; Meta-analysis; ALZHEIMERS-DISEASE; COGNITIVE DECLINE; PROFILE; ASSOCIATION; VARIANTS; COHORT;

D O I：

10.1016/j.atherosclerosis.2013.02.020

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objective: Individual cardiovascular disease (CVD) risk factors are associated with dementia. For the first time, we investigated whether the Framingham CVD risk score-which comprises these multiple risk factors-was also associated with future dementia risk. Methods: Individual participant meta-analysis of two large, general population cohort studies (N = 11,887). For the purposes of comparison of the dementia results, we also examined the association between the Framingham CVD risk score and CVD-related death. Results: Framingham CVD risk score was associated with dementia death (hazard ratio per 10% increased risk, 95% confidence interval: 4.00, 2.44-6.56). Adjusting for age eliminated this association (1.04, 0.53-2.01); similarly, age explained 88% of the ability of the Framingham CVD risk score to predict CVD death. Conclusions: The Framingham CVD risk score was no more strongly associated with future dementia than age. It therefore offers no added value in predicting dementia. (C) 2013 Elsevier Ireland Ltd. All rights reserved.

引用

页码：256 / 258

页数：3

共 15 条

[1] General cardiovascular risk profile for use in primary care - The Framingham Heart Study [J].

D'Agostino, Ralph B. ;

Vasan, Ramachandran S. ;

Pencina, Michael J. ;

Wolf, Philip A. ;

Cobain, Mark ;

Massaro, Joseph M. ;

Kannel, William B. .

CIRCULATION, 2008, 117 (06) :743-753

[2] Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease [J].

Harold, Denise ;

Abraham, Richard ;

Hollingworth, Paul ;

Sims, Rebecca ;

Gerrish, Amy ;

Hamshere, Marian L. ;

Pahwa, Jaspreet Singh ;

Moskvina, Valentina ;

Dowzell, Kimberley ;

Williams, Amy ;

Jones, Nicola ;

Thomas, Charlene ;

Stretton, Alexandra ;

Morgan, Angharad R. ;

Lovestone, Simon ;

Powell, John ;

Proitsi, Petroula ;

Lupton, Michelle K. ;

Brayne, Carol ;

Rubinsztein, David C. ;

Gill, Michael ;

Lawlor, Brian ;

Lynch, Aoibhinn ;

Morgan, Kevin ;

Brown, Kristelle S. ;

Passmore, Peter A. ;

Craig, David ;

McGuinness, Bernadette ;

Todd, Stephen ;

Holmes, Clive ;

Mann, David ;

Smith, A. David ;

Love, Seth ;

Kehoe, Patrick G. ;

Hardy, John ;

Mead, Simon ;

Fox, Nick ;

Rossor, Martin ;

Collinge, John ;

Maier, Wolfgang ;

Jessen, Frank ;

Schuermann, Britta ;

van den Bussche, Hendrik ;

Heuser, Isabella ;

Kornhuber, Johannes ;

Wiltfang, Jens ;

Dichgans, Martin ;

Froelich, Lutz ;

Hampel, Harald ;

Huell, Michael .

NATURE GENETICS, 2009, 41 (10) :1088-U61

[3] AUDIT OF NECROPSIES IN A BRITISH DISTRICT GENERAL-HOSPITAL [J].

HARRIS, MD ;

BLUNDELL, JW .

JOURNAL OF CLINICAL PATHOLOGY, 1991, 44 (10) :862-865

[4] A mutation in APP protects against Alzheimer's disease and age-related cognitive decline [J].

Jonsson, Thorlakur ;

Atwal, Jasvinder K. ;

Steinberg, Stacy ;

Snaedal, Jon ;

Jonsson, Palmi V. ;

Bjornsson, Sigurbjorn ;

Stefansson, Hreinn ;

Sulem, Patrick ;

Gudbjartsson, Daniel ;

Maloney, Janice ;

Hoyte, Kwame ;

Gustafson, Amy ;

Liu, Yichin ;

Lu, Yanmei ;

Bhangale, Tushar ;

Graham, Robert R. ;

Huttenlocher, Johanna ;

Bjornsdottir, Gyda ;

Andreassen, Ole A. ;

Jonsson, Erik G. ;

Palotie, Aarno ;

Behrens, Timothy W. ;

Magnusson, Olafur T. ;

Kong, Augustine ;

Thorsteinsdottir, Unnur ;

Watts, Ryan J. ;

Stefansson, Kari .

NATURE, 2012, 488 (7409) :96-99

[5] Predictive utility of the Framingham general cardiovascular disease risk profile for cognitive function: evidence from the Whitehall II study [J].

Kaffashian, Sara ;

Dugravot, Aline ;

Nabi, Hermann ;

Batty, G. David ;

Brunner, Eric ;

Kivimaeki, Mika ;

Singh-Manoux, Archana .

EUROPEAN HEART JOURNAL, 2011, 32 (18) :2326-2332

[6] Multimarker Prediction of Coronary Heart Disease Risk The Women's Health Initiative [J].

Kim, Hyeon Chang ;

Greenland, Philip ;

Rossouw, Jacques E. ;

Manson, JoAnn E. ;

Cochrane, Barbara B. ;

Lasser, Norman L. ;

Limacher, Marian C. ;

Lloyd-Jones, Donald M. ;

Margolis, Karen L. ;

Robinson, Jennifer G. .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2010, 55 (19) :2080-2091

[7] Comparing predictors of conversion and decline in mild cognitive impairment [J].

Landau, S. M. ;

Harvey, D. ;

Madison, C. M. ;

Reiman, E. M. ;

Foster, N. L. ;

Aisen, P. S. ;

Petersen, R. C. ;

Shaw, L. M. ;

Trojanowski, J. Q. ;

Jack, C. R., Jr. ;

Weiner, M. W. ;

Jagust, W. J. .

NEUROLOGY, 2010, 75 (03) :230-238

[8] Longitudinal Change of Biomarkers in Cognitive Decline [J].

Lo, Raymond Y. ;

Hubbard, Alan E. ;

Shaw, Leslie M. ;

Trojanowski, John Q. ;

Petersen, Ronald C. ;

Aisen, Paul S. ;

Weiner, Michael W. ;

Jagust, William J. .

ARCHIVES OF NEUROLOGY, 2011, 68 (10) :1257-1266

[9] Cohort Profile: The Health Survey for England [J].

Mindell, Jennifer ;

Biddulph, Jane P. ;

Hirani, Vasant ;

Stamatakis, Emanuel ;

Craig, Rachel ;

Nunn, Susan ;

Shelton, Nicola .

INTERNATIONAL JOURNAL OF EPIDEMIOLOGY, 2012, 41 (06) :1585-1593

[10] Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease [J].

Naj, Adam C. ;

Jun, Gyungah ;

Beecham, Gary W. ;

Wang, Li-San ;

Vardarajan, Badri Narayan ;

Buros, Jacqueline ;

Gallins, Paul J. ;

Buxbaum, Joseph D. ;

Jarvik, Gail P. ;

Crane, Paul K. ;

Larson, Eric B. ;

Bird, Thomas D. ;

Boeve, Bradley F. ;

Graff-Radford, Neill R. ;

De Jager, Philip L. ;

Evans, Denis ;

Schneider, Julie A. ;

Carrasquillo, Minerva M. ;

Ertekin-Taner, Nilufer ;

Younkin, Steven G. ;

Cruchaga, Carlos ;

Kauwe, John S. K. ;

Nowotny, Petra ;

Kramer, Patricia ;

Hardy, John ;

Huentelman, Matthew J. ;

Myers, Amanda J. ;

Barmada, Michael M. ;

Demirci, F. Yesim ;

Baldwin, Clinton T. ;

Green, Robert C. ;

Rogaeva, Ekaterina ;

St George-Hyslop, Peter ;

Arnold, Steven E. ;

Barber, Robert ;

Beach, Thomas ;

Bigio, Eileen H. ;

Bowen, James D. ;

Boxer, Adam ;

Burke, James R. ;

Cairns, Nigel J. ;

Carlson, Chris S. ;

Carney, Regina M. ;

Carroll, Steven L. ;

Chui, Helena C. ;

Clark, David G. ;

Corneveaux, Jason ;

Cotman, Carl W. ;

Cummings, Jeffrey L. ;

DeCarli, Charles .

NATURE GENETICS, 2011, 43 (05) :436-+

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