Combining particle size distribution and isothermal calorimetry data to determine the reaction kinetics of α-tricalcium phosphate-water mixtures

被引：40

作者：

Bohner, M ^{[1
]}

Malsy, AK ^{[1
]}

Camiré, CL ^{[1
]}

Gbureck, U ^{[1
]}

机构：

[1] Dr HC Robert Mathys Fdn, CH-2544 Bettlach, Switzerland

来源：

ACTA BIOMATERIALIA | 2006年 / 2卷 / 03期

关键词：

calcium phosphate; cement; kinetics; particle size distribution; bone substitute;

D O I：

10.1016/j.actbio.2006.01.003

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Many calcium phosphate bone substitutes are based on the use of alpha-tricalcium phosphate (alpha-TCP) powder. This compound has been intensively studied, but some aspects of alpha-TCP reactivity are still controversial. The goal of this study was to determine the setting kinetics of alpha-TCP based on a new approach that compared particle size distribution data to isothermal calorimetry data. Results indicated that alpha-TCP conversion is mostly controlled by surface reactions, with at later stages a diffusion-controlled mechanism. The presence of an X-ray amorphous alpha-TCP fraction in the crystalline alpha-TCP powder increased the dissolution rate threefold, without modifying the reaction mechanism. (C) 2006 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.

引用

页码：343 / 348

页数：6

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