Association of Lipopolysaccharide-Toll-Like Receptor 4 Signaling and Microalbuminuria in Patients with Type 2 Diabetes Mellitus

被引:4
|
作者
Zhang, Lijuan [1 ]
Zhang, Yuanjun [2 ,3 ]
Liu, Juxiang [2 ,3 ]
Li, Yonghong [4 ]
Quan, Jinxing [2 ,3 ]
机构
[1] Gansu Prov Hosp, Dept Blood Transfus, Lanzhou, Peoples R China
[2] Gansu Prov Hosp, Dept Endocrinol, Lanzhou, Peoples R China
[3] Key Lab Endocrine & Metab Dis Gansu Prov, Lanzhou, Peoples R China
[4] Gansu Prov Hosp, Inst Clin & Translat Med, Lanzhou, Peoples R China
来源
DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY | 2022年 / 15卷
基金
中国国家自然科学基金;
关键词
intestinal mucosal barrier; microalbuminuria; type 2 diabetes mellitus; lipopolysaccharide; toll-like receptor 4; KIDNEY-DISEASE; GUT MICROBIOTA; METABOLIC ENDOTOXEMIA; HUMAN MONOCYTES; INFLAMMATION; OBESITY; SERUM; COMPLICATIONS; PATHOGENESIS; EXPRESSION;
D O I
10.2147/DMSO.S377776
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Purpose: Intestinal flora imbalance has been implicated in the activation of innate immunity in the kidneys. However, little is known about the potential links between lipopolysaccharide (LPS)-toll-like. receptor 4 (TLR4) signaling activated by intestinal barrier dysfunction and microalbuminuria in type 2 diabetes mellitus (T2DM).Patients and Methods: 61 patients with T2DM were stratified based on the absence (n=32) or presence (n=29) of microalbuminuria. There were also 28 control subjects. Urinary albumin excretion rate (UAER), serum levels of LPS, D-lactic acid (DLA), diamine oxidase (DAO), fasting blood glucose (FBG), interleukin-6 (IL-6), glycosylated hemoglobin A1 (HbA1c), and high-sensitivity C-reactive protein (hs-CRP), and TLR4 expression in peripheral blood mononuclear cells (PBMCs) were measured.Results: hs-CRP, IL-6, LPS, DLA, DAO, and TLR4 were markedly increased in subjects with T2DM compared to the controls (P < 0.05 for all). Moreover, LPS was positively correlated with FBG, HbA1c, hs-CRP, IL-6, UAER, DLA, DAO, and TLR4 (P < 0.05 for all). In addition, TLR4 was positively correlated with UAER, hs-CRP, FBG, DLA, HbA1c, and LPS (P < 0.05 for all). In regression analyses, TLR4, LPS, HbA1c, and hs-CRP were independently associated with UAER (P < 0.05 for all), while FBG, LPS, TLR4, and hs-CRP (P < 0.05 for all) were found to be risk factors for microalbuminuria in T2DM.Conclusion: Intestinal integrity is compromised in subjects with T2DM, and the activation of LPS-TLR4 signaling might play an important role in the development of microalbuminuria in T2DM.
引用
收藏
页码:3143 / 3152
页数:10
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