Increased production of IL-17 in children with autism spectrum disorders and co-morbid asthma

被引：72
作者：
Akintunde, Marjannie Eloi [1 ,2 ]
Rose, Melissa [2 ,3 ,4 ]
Krakowiak, Paula [3 ,4 ]
Heuer, Luke [1 ,3 ]
Ashwood, Paul [2 ,3 ,5 ]
Hansen, Robin [2 ,3 ,6 ]
Hertz-Picciotto, Irva [2 ,3 ,4 ]
de Water, Judy Van [1 ,2 ,3 ]
机构：
[1] Univ Calif Davis, Div Rheumatol Allergy & Clin Immunol, Sch Med, Davis, CA 95616 USA
[2] Univ Calif Davis, NIEHS Ctr Childrens Environm Hlth, Davis, CA 95616 USA
[3] Univ Calif Davis, MIND Inst, Davis, CA 95616 USA
[4] Univ Calif Davis, Sch Publ Hlth Sci, Davis, CA 95616 USA
[5] Sch Med, Dept Microbiol & Immunol, Washington, DC USA
[6] Univ Calif Davis, Sch Med, Dept Pediat, Davis, CA 95616 USA
来源：
JOURNAL OF NEUROIMMUNOLOGY | 2015年 / 286卷
关键词：
Autism; IL-17; Asthma; Food allergies; T-CELLS; IMMUNE; INTERLEUKIN-17; LYMPHOCYTES; ENVIRONMENT; EXPRESSION; RESPONSES; RISK;
D O I：
10.1016/j.jneuroim.2015.07.003
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Inflammation and asthma have both been reported in some children with autism spectrum disorder (ASD). To further assess this connection, peripheral immune cells isolated from young children with ASD and typically developing (TD) controls and the production of cytokines IL-17, -13, and -4 assessed following ex vivo mitogen stimulation. Notably, IL-17 production was significantly higher following stimulation in ASD children compared to controls. Moreover, IL-17 was increased in ASD children with co-morbid asthma compared to controls with the same condition. In conclusion, children with ASD exhibited a differential response to T cell stimulation with elevated IL-17 production compared to controls. (C) 2015 Elsevier B.V. All rights reserved.
引用
收藏
页码：33 / 41
页数：9
相关论文
共 63 条
  • [1] A lack of association between elevated serum levels of S100B protein and autoimmunity in autistic children
    Al-Ayadhi, Laila Yousef
    Mostafa, Gehan Ahmed
    [J]. JOURNAL OF NEUROINFLAMMATION, 2012, 9
  • [2] Ashwood P., 2010, BRAIN BEHAV IMMUN
  • [3] Altered T cell responses in children with autism
    Ashwood, Paul
    Krakowiak, Paula
    Hertz-Picciotto, Irva
    Hansen, Robin
    Pessah, Isaac N.
    Van de Water, Judy
    [J]. BRAIN BEHAVIOR AND IMMUNITY, 2011, 25 (05) : 840 - 849
  • [4] Associations of impaired behaviors with elevated plasma chemokines in autism spectrum disorders
    Ashwood, Paul
    Krakowiak, Paula
    Hertz-Picciotto, Irva
    Hansen, Robin
    Pessah, Isaac N.
    Van de Water, Judy
    [J]. JOURNAL OF NEUROIMMUNOLOGY, 2011, 232 (1-2) : 196 - 199
  • [5] Elevated plasma cytokines in autism spectrum disorders provide evidence of immune dysfunction and are associated with impaired behavioral outcome
    Ashwood, Paul
    Krakowiak, Paula
    Hertz-Picciotto, Irva
    Hansen, Robin
    Pessah, Isaac
    Van de Water, Judy
    [J]. BRAIN BEHAVIOR AND IMMUNITY, 2011, 25 (01) : 40 - 45
  • [6] Preliminary evidence of the in vitro effects of BDE-47 on innate immune responses in children with autism spectrum disorders
    Ashwood, Paul
    Schauer, Joseph
    Pessah, Isaac N.
    de Water, Judy Van
    [J]. JOURNAL OF NEUROIMMUNOLOGY, 2009, 208 (1-2) : 130 - 135
  • [7] Decreased transforming growth factor beta1 in autism: A potential link between immune dysregulation and impairment in clinical behavioral outcomes
    Ashwood, Paul
    Enstrom, Amanda
    Krakowiak, Paula
    Hertz-Picciotto, Irva
    Hansen, Robin L.
    Croen, Lisa A.
    Ozonoff, Sally
    Pessah, Isaac N.
    Van de Water, Judy
    [J]. JOURNAL OF NEUROIMMUNOLOGY, 2008, 204 (1-2) : 149 - 153
  • [8] The immune response in autism: a new frontier for autism research
    Ashwood, Paul
    Wills, Sharifia
    Van De Water, Judy
    [J]. JOURNAL OF LEUKOCYTE BIOLOGY, 2006, 80 (01) : 1 - 15
  • [9] Atopic features in early childhood autism
    Bakkaloglu, Betul
    Anlar, Banu
    Anlar, F. Yasar
    Oektem, Ferhunde
    Pehlivantuerk, Berna
    Uenal, Fatih
    Ozbesler, Cengiz
    Goekler, Bahar
    [J]. EUROPEAN JOURNAL OF PAEDIATRIC NEUROLOGY, 2008, 12 (06) : 476 - 479
  • [10] Interleukin-17 in sputum correlates with airway hyperresponsiveness to methacholine
    Barczyk, A
    Pierzchala, W
    Sozañska, E
    [J]. RESPIRATORY MEDICINE, 2003, 97 (06) : 726 - 733
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